Sort   by:  
 Page size 
ProteomicsNaa30 is critically involved in maintaining mitochondrial and Golgi integrity
N-terminal acetylation is one of the most common protein modifications in eukaryotes, with emerging roles in regulating protein quality and stoichiometry and targeting and complex formation. The NatC complex is one of the three major N-terminal acetyltransferases (NATs). Here, we partially defined t...
ORGANISM(S): Homo sapiens (Human) 
2016-10-05 | PXD000930 | Pride
Golgi Mitochondria Naa30 Human N-terminal cofradic 
ProteomicsGOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway
Glycosylation plays an important role for modifications of lipids and sorting of proteins that is regulated by asymmetric intra-Golgi distribution and SPPL3-mediated cleavage of Golgi enzymes. We found that cells lacking the Golgi N-acetylglucosamine phosphotransferase (GNPT) retention factor LYSET/...
ORGANISM(S): Homo sapiens (Human) 
2024-11-27 | PXD052083 | Pride
Golgi apparatus  lysosomes  mannose 6-phophate tagging  glycosyltransferase secretion  intramembrane proteolysis  copi vesicles 
ProteomicsAn organellar Nα-acetyltransferase Naa60 acetylates cytosolic N-termini of transmembrane proteins and maintains Golgi integrity
N-terminal acetylation is a major and vital protein modification catalysed by N-terminal acetyltransferases (NATs). NatF or Nα-acetyltransferase 60 (Naa60) was recently identified as a NAT in higher eukaryotes. Here, we found that Naa60 differs from all other known NATs by its Golgi localization. A ...
ORGANISM(S): Homo sapiens (Human) 
2019-06-04 | PXD001155 | Pride
Naa60 N-terminal cofradic 
UnknownCOG6 interacts with a subset of the Golgi SNAREs and is important for the Golgi complex integrity.
Not available
S-EPMC3538890 | biostudies-literature
UnknownTM9SF2 Maintains Golgi Integrity and Regulates Ricin-Induced Cytotoxicity.
Not available
S-EPMC12116000 | biostudies-literature
UnknownITCH regulates Golgi integrity and proteotoxicity in neurodegeneration.
Not available
S-EPMC12551705 | biostudies-literature
UnknownA SEPT1-based scaffold is required for Golgi integrity and function.
Not available
S-EPMC6382012 | biostudies-literature
GenomicsImportance of Golgi homeostasis in hair quality: Grasp55 is crucial for cuticle formation
Importance of Golgi homeostasis in hair quality: Grasp55 is crucial for cuticle formation
PRJNA1335115 | ENA
ProteomicsThe Golgi stacking protein GRASP55 is targeted by the natural compound prodigiosin
The bacterial secondary metabolite prodigiosin has been shown to exert anticancer, antimalarial, antibacterial and immunomodulatory properties. With regard to cancer, it has been reported to affect cancer cells but not non-malignant cells, rendering prodigiosin a promising lead compound for anticanc...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043247 | Pride
Prodigiosin  golgi apparatus  natural compound  autophagy  target identification 
UnknownGolgin45-Syntaxin5 Interaction Contributes to Structural Integrity of the Golgi Stack.
Not available
S-EPMC6713708 | biostudies-literature
Sort   by:  
 Page size