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ProteomicsAn organellar Nα-acetyltransferase Naa60 acetylates cytosolic N-termini of transmembrane proteins and maintains Golgi integrity
N-terminal acetylation is a major and vital protein modification catalysed by N-terminal acetyltransferases (NATs). NatF or Nα-acetyltransferase 60 (Naa60) was recently identified as a NAT in higher eukaryotes. Here, we found that Naa60 differs from all other known NATs by its Golgi localization. A ...
ORGANISM(S): Homo sapiens (Human) 
2019-06-04 | PXD001155 | Pride
Naa60 N-terminal cofradic 
ProteomicsPlasma membrane analysis of NAA60-deficient mouse mammary tumor cells
Analysis of plasma membrane enriched protein fractions from NAA60-proficient or deficient mouse mammary tumor cells.
ORGANISM(S): Mus musculus (Mouse) 
2025-08-21 | PXD035143 | Pride
Plasma membrane isolation Naa60 
Proteomicsplasma membrane anchored NAA60 N-terminal acetylation profiling in Arabidopsis thaliana
N-terminal acetylation (NTA) is one of the most abundant protein modifications in eukaryotes and is catalysed in humans by seven N-acetyltransferases. AtNAA60 localizes to the plasma membrane in vivo by an α-helical membrane anchor at its C-terminus. In this study, we investigated the Arabidopsis th...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-07-15 | PXD016494 | Pride
Acetyltransferase N-acetylome N-terminal acetylation Quantitative proteomics Silpronaq 
UnknownNAA60 facilitates LRRC8A- and LRRC8D-mediated platinum drug uptake.
Not available
S-EPMC12501270 | biostudies-literature
UnknownMolecular determinants of the N-terminal acetyltransferase Naa60 anchoring to the Golgi membrane.
Not available
S-EPMC5399128 | biostudies-literature
UnknownBiallelic NAA60 variants with impaired n-terminal acetylation capacity cause autosomal recessive primary familial brain calcifications.
Not available
S-EPMC10937998 | biostudies-literature
UnknownNAA60 (HAT4): the newly discovered bi-functional Golgi member of the acetyltransferase family.
Not available
S-EPMC9769039 | biostudies-literature
UnknownStructure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase.
Not available
S-EPMC4993997 | biostudies-literature
UnknownHuman N-Alpha-Acetyltransferase 60 Promotes Influenza A Virus Infection by Dampening the Interferon Alpha Signaling.
Not available
S-EPMC8790067 | biostudies-literature
UnknownCrystal Structure of the Golgi-Associated Human Nα-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation.
Not available
S-EPMC4938767 | biostudies-literature
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