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ProteomicsProteomic Analysis of Huh7, HIEC6, and NCI-H295R cells using High-affinity anti-Golm1 mAb by IP-MS.
we conducted IP-MS strategy to screen its interacting proteins. High-affinity anti-Golm1 mAb and IgG were used in multiple cell lines including Huh7, HIEC6, and NCI-H295R cells. Proteins with more than two peptide segments enriched or exclusively within the Golm1 group were identified as putative in...
ORGANISM(S): Homo sapiens (Human) Homo sapiens 
2026-03-23 | PXD061115 | Pride
Golm1 ip-ms 
GenomicsGOLM1 dictates acquired Lenvatinib resistance by a GOLM1-CSN5 positive feedback loop upon EGFR signaling activation in hepatocellular carcinoma
GOLM1 dictates acquired Lenvatinib resistance by a GOLM1-CSN5 positive feedback loop upon EGFR signaling activation in hepatocellular carcinoma
PRJNA1143404 | ENA
TranscriptomicsGOLM1 dictates acquired Lenvatinib resistance by a GOLM1-CSN5 positive feedback loop upon EGFR signaling activation in hepatocellular carcinoma
Lenvatinib is a multiple receptor tyrosine kinases inhibitor (TKI) authorized for first-line treatment of hepatocellular carcinoma (HCC). However, Lenvatinib resistance is common in HCC clinical treatment, highlighting the urgent need to understand mechanisms of resistance. Here, we identified Golgi...
ORGANISM(S): Homo sapiens 
2024-08-07 | GSE273819 | GEO
TranscriptomicsTranscriptomic profiling of GOLM1 silenced A549 lung adenocarcinoma cells
GOLM1 is a Golgi-resident protein implicated in multiple cancers, but its role in lung adenocarcinoma remains incompletely understood. RNA sequencing was performed on A549 lung adenocarcinoma cells following siRNA-mediated silencing of GOLM1 using two independent siRNAs and a non-targeting control. ...
ORGANISM(S): Homo sapiens 
2026-07-04 | GSE337173 | GEO
UnknownThe functional landscape of Golgi membrane protein 1 (GOLM1) phosphoproteome reveal GOLM1 regulating P53 that promotes malignancy.
Not available
S-EPMC7921442 | biostudies-literature
GenomicsTargeted Ubiquitination and Degradation of GOLM1 by CC-885 Suppresses Hepatocellular Carcinoma Growth and Metastasis
Targeted Ubiquitination and Degradation of GOLM1 by CC-885 Suppresses Hepatocellular Carcinoma Growth and Metastasis
PRJNA1137341 | ENA
TranscriptomicsTargeted Ubiquitination and Degradation of GOLM1 by CC-885 Suppresses Hepatocellular Carcinoma Growth and Metastasis
Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality, necessitating innovative therapeutic approaches. This study demonstrates that the compound CC-885 exerts potent anti-tumor effects in HCC both in vitro and in vivo. CC-885 significantly inhibited proliferation, migration, and inv...
ORGANISM(S): Homo sapiens 
2024-10-11 | GSE272556 | GEO
GenomicsAberrant expression of GOLM1 protects ALK+ anaplastic large cell lymphoma from apoptosis by enhancing BCL-XL stability
Aberrant expression of GOLM1 protects ALK+ anaplastic large cell lymphoma from apoptosis by enhancing BCL-XL stability
PRJNA933116 | ENA
UnknownGOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells.
Not available
S-EPMC8558645 | biostudies-literature
UnknownGOLM1 depletion modifies cellular sphingolipid metabolism and adversely affects cell growth.
Not available
S-EPMC9475319 | biostudies-literature
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