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ProteomicsSystematic Identification of Post-Transcriptional Regulatory Modules
In our cells, a limited number of RNA binding proteins (RBPs) are responsible for all aspects of RNA metabolism across the entire transcriptome. To accomplish this, RBPs form regulatory units that act on specific target regulons. However, the landscape of RBP combinatorial interactions remains poorl...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD041608 | Pride
K562 Rbp 
TranscriptomicsRegulatory consequences of TARBP2 knock-down in MDA-LM2 cell-line
siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant up-regulation of sRSE-carrying transcripts. Two independent siRNAs were used to knock down TARBP2 in metastatic MDA-LM2 cells. The cells were then subjected to transcripome prof...
ORGANISM(S): Homo sapiens 
2014-07-24 | E-GEOD-49611 | biostudies-arrayexpress
TranscriptomicsRegulatory consequences of ZNF395 knock-down in MDA-LM2-shTARBP2 cell-line
shRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of ZNF395 resulted in a significant up-regulation in several key oncogenes. ZNF395 was knocked-down, via expression of short-hairpin RNAs targeting its transcript. The cells were then subjected to transcripome pro...
ORGANISM(S): Homo sapiens 
2014-07-24 | E-GEOD-49613 | biostudies-arrayexpress
TranscriptomicsRegulatory consequences of TARBP2 knock-down in Dicer-null MEFs
siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant up-regulation of sRSE-carrying transcripts. Two independent siRNAs were used to knock down TARBP2 in metastatic Dicer-null cells. The cells were then subjected to transcripome p...
ORGANISM(S): Mus musculus 
2014-07-24 | E-GEOD-56949 | biostudies-arrayexpress
TranscriptomicsRegulatory consequences of TARBP2 knock-down in MDA-LM2-shDicer cell-line
siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant up-regulation of sRSE-carrying transcripts. Two independent siRNAs were used to knock down TARBP2 in metastatic MDA-LM2 shDicer cells. The cells were then subjected to transcrip...
ORGANISM(S): Homo sapiens 
2014-07-24 | E-GEOD-56950 | biostudies-arrayexpress
TranscriptomicsRegulatory consequences of TARBP2 knock-down in293T cell-line
siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant up-regulation of sRSE-carrying transcripts. Two independent siRNAs were used to knock down TARBP2 in metastatic 293T cells. The cells were then subjected to transcripome profili...
ORGANISM(S): Homo sapiens 
2014-07-24 | E-GEOD-56945 | biostudies-arrayexpress
TranscriptomicsRegulatory consequences of TARBP2 over-expression in MDA-231 cell-line
Transient transfection of TARBP2 expression vectors (along with GFP controls) followed by transcriptomic profiling revealed that over-expression of TARBP2 resulted in a significant enrichment of sRSE-carrying transcripts among the down-regulated transcripts. Transient transfection of CMV-driven TARB...
ORGANISM(S): Homo sapiens 
2014-07-24 | E-GEOD-56948 | biostudies-arrayexpress
TranscriptomicsRegulatory consequences of TARBP2 knock-down in CN-LM1a cell-line
siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant up-regulation of sRSE-carrying transcripts. Two independent siRNAs were used to knock down TARBP2 in metastatic CN-LM1a cells. The cells were then subjected to transcripome prof...
ORGANISM(S): Homo sapiens 
2014-07-24 | E-GEOD-56947 | biostudies-arrayexpress
TranscriptomicsRegulatory consequences of TARBP2 knock-down in MDA-LM2 cell-line [stability experiment]
siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant increase in the stability of sRSE-carrying transcripts. Two independent siRNAs were used to knock down TARBP2 in metastatic MDA-LM2 cells. The cells were then subjected to whole...
ORGANISM(S): Homo sapiens 
2014-07-24 | E-GEOD-49612 | biostudies-arrayexpress
TranscriptomicsIn-culture titration experiment for sRSE
In order to test the transcriptome-wide functionality of the identified sRSE instances, we performed an in vivo titration experiment in which synthetic RNA oligonucleotides harboring tandem sRSE1 repeats were used as intracellular decoys that would bind the putative trans factor, preventing it from ...
ORGANISM(S): Homo sapiens 
2014-07-24 | E-GEOD-49609 | biostudies-arrayexpress
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