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TranscriptomicsIdentifying genetic determinants needed to establish a human gut symbiont in its habitat
The human gut microbiota is a metabolic organ whose cellular composition is determined by a dynamic process of selection and competition. To identify microbial genes required for establishment of human symbionts in the gut, we developed an approach (insertion-sequencing, or INSeq) based on a mutagen...
ORGANISM(S): Bacteroides thetaiotaomicron 
2009-09-15 | E-GEOD-17712 | biostudies-arrayexpress
MetabolomicsMapping human microbiome drug metabolism by gut bacteria and their genes

Individuals vary widely in their drug responses, which can be dangerous and expensive due to treatment delays and adverse effects. Growing evidence implicates the gut microbiome in this variability, however the molecular mechanisms remain largely unknown. We measured the ability of 76 diverse hum...

2019-07-10 | MTBLS896 | MetaboLights
MetabolomicsIntegrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency
Functional oncogenic links between ErbB2 and ERRα in HER2+ breast cancer patients support a therapeutic benefit of co-targeted therapies. However, ErbB2 and ERRα also play key roles in heart physiology, and this approach could pose a potential liability to cardiovascular health. Herein, using integr...
2022-09-20 | MTBLS795 | MetaboLights
UnknownAnxiety in Angelman Syndrome.
Not available
S-EPMC8803540 | biostudies-literature
MetabolomicsMicrobial transformation of dietary xenobiotics shapes gut microbiome composition

Diet is a major determinant of gut microbiome composition, and variation in diet-microbiome interactions may contribute to variation in their health consequences. Understanding individual differences requires mechanistic understanding of dietary xenobiotics-microbiome interactions. Here, we map i...

2024-08-06 | MTBLS9221 | MetaboLights
TranscriptomicsRNAseq of the human gut commensal Bacteroides thetaiotaomicron wildtype, bt0700 and bt0700 bt3998 (ppGpp0) strains across three conditions: glucose minimal medium, 1h of carbon starvation, and mouse gut colonization
Transcriptional profiles of wildtype and mutant strains bt0700 and bt0700 bt3998 (ppGpp0) of human gut commensal B. thetaiotaomicron were collected to investigate the relevance of the stringent response mediated by the alarmone (p)ppGpp for growth and survival in three different conditions. RNAseq s...
ORGANISM(S): Bacteroides thetaiotaomicron VPI-5482 
2018-07-04 | E-MTAB-6412 | biostudies-arrayexpress
UnknownDel1 Is a Growth Factor for Skeletal Progenitor Cells in the Fracture Callus.
Not available
S-EPMC10452420 | biostudies-literature
GenomicsA Genome-Wide Association Study of Lung Cancer Risk

Three genetic loci for lung cancer risk have been identified by genome-wide association studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not well established. We conducted a GWAS of lung cancer and its major histologic types genotyping 515,922 single n...

phs000336.v1.p1 | EGA
ProteomicsChemical characterization of clostridithiol compounds in Clostridioides difficile
Stable isotope labeling of clostridithiol compounds 1-8 in liquid cultures of Clostridioides difficile upon supplementation of polyamines & relevant precursors containing carbon-13/deuterium labels in a modified minimal media. MS/MS of targeted compounds was collected at 30 eV collision energy. Data...
ORGANISM(S): Clostridioides Difficile (ncbitaxon:1496) 
2025-06-12 | MSV000098168 | MassIVE
ProteomicsA human gut bacterium antagonizes neighboring bacteria by altering their protein folding ability
Human gut microorganisms alter the folding capacity of neighboring cells and suggest new strategy for manipulating microbial community dynamics.
ORGANISM(S): Bacteroides Thetaiotaomicron (ncbitaxon:818) 
2024-08-16 | MSV000095628 | MassIVE
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