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TranscriptomicsProduction of artificial piRNAs in flies and mice
In animals, a discrete class of small RNAs, the piwi-interacting RNAs (piRNAs), guard germ cell genomes against the activity of mobile genetic elements. piRNAs are generated, via an unknown mechanism, from apparently single-stranded precursors that arise from discrete genomic loci, termed piRNA clus...
ORGANISM(S): Mus musculus 
2012-01-01 | E-GEOD-32435 | biostudies-arrayexpress
TranscriptomicsProbing the initiation and effector phases of the somatic piRNA pathway in Drosophila
Combining RNAi in cultured cells and analysis of mutant animals, we probed roles of known piRNA pathway components in the initiation and effector phases of transposon silencing. total RNA and RNA associated with Piwi was isolated and size-fractionated by PAGE into 19-29nt. These were processed and s...
ORGANISM(S): Drosophila melanogaster 
2010-10-25 | E-GEOD-24108 | biostudies-arrayexpress
TranscriptomicsHigh-througput sequencing of the rtel1 mutant
RNA sequencing performed on the root tips of rtel1 mutants and Col-0
ORGANISM(S): Arabidopsis thaliana 
2016-09-01 | E-MTAB-2943 | biostudies-arrayexpress
TranscriptomicsArabidopsis thaliana RNase H2 deficiency counteracts the needs for the WEE1 checkpoint kinase but triggers genome instability
RNA sequencing performed on the root tips of wee1-1 and wee1-1/rnh2a mutants, treated for 24h with or without 2mM hydroxyurea.
ORGANISM(S): Arabidopsis thaliana 
2016-05-20 | E-MTAB-2590 | biostudies-arrayexpress
TranscriptomicsHierarchical rules for Argonaute loading in Drosophila
Drosophila Argonaute-1 and Argonaute-2 differ in function and small RNA content. AGO2 binds to siRNAs, whereas AGO1 is almost exclusively occupied by microRNAs. microRNA duplexes are intrinsically asymmetric, with one strand, the miR strand, preferentially entering AGO1 to recognize and regulate the...
ORGANISM(S): Drosophila melanogaster 
2009-11-15 | E-GEOD-17734 | biostudies-arrayexpress
UnknownCabozantinib in patients with advanced prostate cancer: results of a phase II randomized discontinuation trial.
Not available
S-EPMC4110249 | biostudies-literature
TranscriptomicsSmall RNA-seq from ENCODE/Cold Spring Harbor Lab
This data was generated by ENCODE. If you have questions about the data, contact the submitting laboratory directly (Jonathan Preall jpreall@cshl.edu (Generation 0 Data from Hannon Lab), Carrie Davis davisc@cshl.edu (experimental), Alex Dobin dobin@cshl.edu (computational), Wei Lin wlin@cshl.edu (co...
ORGANISM(S): Homo sapiens 
2010-10-08 | E-GEOD-24565 | biostudies-arrayexpress
UnknownColorectal cancer among inflammatory bowel disease patients: risk factors and prevalence compared to the general population.
Not available
S-EPMC10443703 | biostudies-literature
UnknownAzithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC7884931 | biostudies-literature
UnknownAspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC8598213 | biostudies-literature
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