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Unknownc.1103T>C (p.Ile368Th) de novo Variant in Synaptotagmin 1 (SYT1) Gene is Pathogenic, Leading to an Ultra-Rare Neurodevelopmental Disorder: The Baker-Gordon Syndrome.
Not available
S-EPMC10822096 | biostudies-literature
UnknownEffect of multifunctional cationic polymer coatings on mitigation of broad microbial pathogens.
Not available
S-EPMC11370243 | biostudies-literature
TranscriptomicsFailures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during the chronic denervation that results from slow axon growth. This impairs axonal regeneration and ca...
ORGANISM(S): Mus musculus 
2020-10-14 | E-MTAB-9640 | biostudies-arrayexpress
UnknownPNPLA6 mutations cause Boucher-Neuhauser and Gordon Holmes syndromes as part of a broad neurodegenerative spectrum.
Not available
S-EPMC3891450 | biostudies-literature
Proteomicsc-Myc uses Cul4b to preserve genome stability and promote CD8+ T cell-mediated antiviral immune responses
During infection, virus-specific CD8+ T cells undergo rapid bursts of proliferation and differentiate into effector cells that kill virus infected cells and reduce viral load. This rapid clonal expansion can put T cells at significant risk for replication-induced DNA damage. We found that c-Myc util...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-29 | PXD041220 | Pride
C-myc Cd8+ t cells Replication stress Antiviral immune responses E3 ubiquitin ligases Cul4b 
TranscriptomicsInsulin-like Signaling Determines Survival During Stress via Post Transcriptional Mechanisms in C. elegans.
The insulin-like signaling (ILS) pathway regulates metabolism and is known to modulate adult lifespan in C. elegans. Altered stress responses and resistance to a wide range of stressors are also associated with changes in ILS and contribute to enhanced longevity. The transcription factors DAF-16 and...
ORGANISM(S): Caenorhabditis elegans 
2010-06-17 | E-GEOD-22383 | biostudies-arrayexpress
UnknownFunctionalisation of ethereal-based saturated heterocycles with concomitant aerobic C-H activation and C-C bond formation.
Not available
S-EPMC9337743 | biostudies-literature
UnknownCanine hereditary ataxia in old english sheepdogs and gordon setters is associated with a defect in the autophagy gene encoding RAB24.
Not available
S-EPMC3916225 | biostudies-literature
GenomicsC/EBP Maintains Chromatin Accessibility in Liver and Facilitates Glucocorticoid Receptor Recruitment to Steroid Response Elements
DNase-seq and ChIP-seq determine that C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements DNase-seq and ChIP-seq (GR, C/EBPb and RNAPII) in intact liver from adrenalectomized mice injected with dex (1h)
ORGANISM(S): Mus musculus 
2013-04-17 | E-GEOD-46047 | biostudies-arrayexpress
UnknownMutations in PIEZO2 cause Gordon syndrome, Marden-Walker syndrome, and distal arthrogryposis type 5.
Not available
S-EPMC4067551 | biostudies-literature
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