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TranscriptomicsPenicillium marneffei: Gene expression profiling of hyphal and yeast cells and during conidiation
Penicillium marneffei (Talaromyces marneffei) is an opportunistic human pathogen that can grow in a multicellular hyphal form at 25M-BM-0C or a unicellular fission yeast form at 37M-BM-0C, and can switch between these two forms in response to temperature. The yeast form is found in infected individu...
ORGANISM(S): Talaromyces marneffei 
2013-11-21 | E-GEOD-51109 | biostudies-arrayexpress
TranscriptomicsKey hub and bottleneck genes differentiate the macrophage response to virulent and attenuated Mycobacterium bovis
Mycobacterium bovis is an intracellular pathogen that causes tuberculosis in cattle. Following infection, the pathogen resides and persists inside host macrophages by subverting host immune responses via a diverse range of mechanisms. Here, a high-density bovine microarray platform was used to exami...
ORGANISM(S): Bos taurus 
2014-08-01 | E-GEOD-59774 | biostudies-arrayexpress
MetabolomicsSequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID

The post-acute sequelae of COVID-19 (PASC), also known as long COVID, is often associated with debilitating symptoms and adverse multisystem consequences. We obtain plasma samples from 117 individuals during and 6 mth following their acute phase of infection to comprehensively profile and as...

2024-02-23 | MTBLS7337 | MetaboLights
TranscriptomicsPenicillium marneffei: Gene expression profiling during the dimorphic switch
Penicillium marneffei (Talaromyces marneffei) is an opportunistic human pathogen that can grow in a multicellular hyphal form at 25M-BM-0C or a unicellular fission yeast form at 37M-BM-0C, and can switch between these two forms in response to temperature. The yeast form is found in infected individu...
ORGANISM(S): Talaromyces marneffei 
2013-11-21 | E-GEOD-51110 | biostudies-arrayexpress
TranscriptomicsMicroarray Expression Analysis of SIV infection of Sooty Mangabeys
Natural SIV infection of sooty mangabeys (SMs) does not progress to disease despite chronic virus replication. In contrast to pathogenic SIV infection of rhesus macaques (RMs), chronic SIV infection of SMs is characterized by low immune activation. To elucidate the mechanisms underlying this phenoty...
ORGANISM(S): Cercocebus torquatus atys 
2010-03-08 | E-GEOD-16147 | biostudies-arrayexpress
TranscriptomicsWhole-transcriptome, high-throughput RNA sequence analysis of the bovine macrophage response to MycobacteriumM-BM- bovis infection in vitro
Background: MycobacteriumM-BM- bovis, the causative agent of bovine tuberculosis, is an intracellular pathogen that can persist inside host macrophages during infection via a diverse range of mechanisms that subvert the host immune response. In the current study, we have analysed and compared the tr...
ORGANISM(S): Bos taurus 
2013-03-26 | E-GEOD-45439 | biostudies-arrayexpress
TranscriptomicsRNA-seq transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis
In the present study, we have analyzed the peripheral blood leukocyte (PBL) transcriptome of eight natural M. bovis-infected and eight age- and sex-matched non-infected control Holstein-Friesian animals using RNA-seq. In addition, we compared gene expression profiles generated using RNA-seq with tho...
ORGANISM(S): Bos taurus 
2014-08-18 | E-GEOD-60265 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression of bovine monocyte-derived macrophages in response to in vitro challenge with Mycobacterium bovis
Background: Mycobacterium bovis, the causative agent of bovine tuberculosis, is a major cause of mortality in global cattle populations. Macrophages are among the first cells types to encounter M. bovis following exposure and the response elicited by these cells is pivotal in determining the outcome...
ORGANISM(S): Bos taurus 
2011-12-31 | E-GEOD-33309 | biostudies-arrayexpress
TranscriptomicsSequence discrimination study
The use of DNA microarrays to identify nucleotide variation is almost 20 years old. A variety of improvements in probe design and experimental conditions have brought this technology to the point that single-nucleotide differences can be efficiently detected in unmixed samples, although developing r...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-18 | E-GEOD-19319 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of human HNF3b and E2F4, and mouse NeuroD1, for THEME analysis
Genome-wide chromatin-immunoprecipitation (ChIP-chip) detects binding of transcriptional regulators to DNA in vivo at low resolution. Motif discovery algorithms can be used to discover sequence patterns in the bound regions that may be recognized by the immunoprecipitated protein. However, the disco...
ORGANISM(S): Mus musculus 
2006-05-09 | E-WMIT-8 | biostudies-arrayexpress
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