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TranscriptomicsDifferential expression of genes in the WT and hupB KO strain of Mycobacterium tuberculosis H37Rv upon iron limitation
HupB is a 28 kDa in Mycobacterium tuberculosis that is co-expressed with the siderophores mycobactin and carboxymycobactin upon iron limitation. High levels of all the three components are seen in low iron (LI; 0.02 M-BM-5g Fe / mL) organisms, with negligible expression in high iron organisms (HI; 8...
ORGANISM(S): Mycobacterium tuberculosis 
2014-03-18 | E-GEOD-53254 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocytes cultured in the presence of M-CSF for 7 days and polarized to M1 or M2 cells to characterize human monocyte-to-macrophage differentiation and polarization
Monocytes mature to macrophages in the presence of the lineage determining cytokine M-CSF. They can be further polarized into M1 or M2 macrophages with distinct functional properties. We used microarrays to detail the global programme of gene expression underlying macrophage maturation and polarizat...
ORGANISM(S): Homo sapiens 
2007-11-02 | E-GEOD-5099 | biostudies-arrayexpress
TranscriptomicsAnalysis of Drosophila salivary glands and Kc cells with depleted levels of linker histone H1 (Illumina smRNA-Seq]
Salivary glands or larval ovaries were isolated from transgenic flies expressing RNAi targeting Nautilus (control) or linker histone H1 using a Tub-Gal4 driver. ~200 larvae were used to isolate salivary glands or ovaries, independently. Total RNA was isolated using Trizol reagent following manufact...
ORGANISM(S): Drosophila melanogaster 
2013-04-22 | E-GEOD-44399 | biostudies-arrayexpress
TranscriptomicsA defect in ATP-citrate lyase links acetyl-CoA production, virulence factor elaboration and virulence in Cryptococcus neoformans
The interaction of Cryptococcus neoformans with phagocytic cells of the innate immune system is a key step in disseminated disease leading to meningoencephalitis in immunocompromised individuals. Transcriptional profiling of cryptococcal cells harvested from cell culture medium or from macrophages ...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2013-08-15 | E-GEOD-41066 | biostudies-arrayexpress
TranscriptomicsThreshold of Biologic Response of the Small Airway Epithelium to Low Levels of Tobacco Smoke
Background: Healthy individuals exposed to low levels of cigarette smoke have a decrement in lung function and higher risk for lung disease compared to unexposed individuals. We hypothesized that healthy individuals exposed to low levels of tobacco smoke must have biologic changes in the small airwa...
ORGANISM(S): Homo sapiens 
2011-02-02 | E-GEOD-19667 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses of murine macrophages to the adenylate cyclase toxin of Bordetella pertussis
Three different recombinant forms of CyaA were used to investigate transcriptional responses of murine bone marrow-derived macrophages (BMDMs) using Affymetrix Mouse Genome Genechips. These forms were enzymically active, invasive CyaA, nonenzymically active, invasive CyaA (CyaA*) and non-enzymically...
ORGANISM(S): Mus musculus 
2013-09-22 | E-GEOD-51075 | biostudies-arrayexpress
TranscriptomicsSimilarities and differences between macrophage polarized gene profiles (Illumina)
The human AA dataset 5 includes the gene expression profile of monocyte-derived macrophages isolated from blood donor buffy coats and plated on TCP in medium containing 10% autologous serum. Cells were stimulated for 120 hours with 50 ng/ml of IL-4, 50 U/ml of IFN-γ plus 12.5 ng/ml of TNF-α, 50 ng/m...
ORGANISM(S): Homo sapiens 
2013-07-26 | E-GEOD-49240 | biostudies-arrayexpress
MetabolomicsMitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Somatic DNMT3A R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To ide...
2025-02-06 | MTBLS12201 | MetaboLights
GenomicsChIP-Seq of human breast cancer cell lines treated with estrogen and tamoxifen to investigate CTCF binding
CCCTC-binding factor (CTCF) is a conserved zinc finger transcription factor involved in chromatin looping. Recent evidence has shown a role for CTCF in ER biology. This experiment maps CTCF binding genome-wide in breast cancer cells and shows that CTCF binding does not change with estrogen or tamo...
ORGANISM(S): Homo sapiens 
2011-12-07 | E-MTAB-740 | biostudies-arrayexpress
Genomicsena-DATASET-BAMS-05-01-2017-02:07:22:122-13 - samples
Whole exome sequencing data for patients with Bosma arhinia microphthalmia syndrome (BAMS). The dataset includes 21 samples from 7 families with BAMS; see Gordon et al, Nature Genetics, 2017.
EGAD00001003130 | EGA
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