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TranscriptomicsGenes differentailly expressed in organ-specific metastatic cells derived from MDA-MB-231 breast cancer cell line
Breast cancer metastasizes to bone, visceral organs, and/or brain depending on the subtypes. Various cell line models have been used to develop gene expression signatures unique to cancer cells that have metastasized to specific organs, although these efforts were not in a uniform setting. In this s...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-66495 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of T47D breast cancer cells following progestin administration in presence or absence of Telapristone
Analysis of the effect of progesterone blockade at the gene expression level. The hypothesis tested in the present study is that elapristone (CDB4124), an antiprogestin, will downregulate genes that are stimulated by R5020, a synthetic progestin, in the T47D breast cancer cell line. Total RNA obtai...
ORGANISM(S): Homo sapiens 
2015-05-15 | E-GEOD-67561 | biostudies-arrayexpress
TranscriptomicsGene Expression Analysis of Thymic Neoplasms
Histologic classification of thymomas has significant limitations since complete surgical excision can be curative. In order to better understand the biology of the disease processes, we performed whole genome gene expression analysis. RNA was extracted from fresh frozen tumors from 36 patients with...
ORGANISM(S): Homo sapiens 
2012-06-30 | E-GEOD-29695 | biostudies-arrayexpress
TranscriptomicsRelationship between Differential Hepatic microRNA Expression and Decreased Hepatic Cytochrome P450 3A Activity in Cirrhosis
Background and Aim: Liver cirrhosis is associated with decreased hepatic cytochrome P4503A (CYP3A) activity but the pathogenesis of this phenomenon is not well elucidated. In this study, we examined if certain microRNAs (miRNA) are associated with decreased hepatic CYP3A activity in cirrhosis. He...
ORGANISM(S): Homo sapiens 
2013-08-15 | E-GEOD-49012 | biostudies-arrayexpress
TranscriptomicsIdentification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines
Metastasis suppressor genes (MSGs) have contributed to an understanding of regulatory pathways unique to the lethal metastatic process. When re-expressed in experimental models, MSGs block cancer spread to, and colonization of distant sites without affecting primary tumor formation. On a single MSG ...
ORGANISM(S): Homo sapiens 
2013-12-27 | E-GEOD-53668 | biostudies-arrayexpress
TranscriptomicsA molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers
Specific changes in gene expression during cancer initiation should enable discovery of biomarkers for risk assessment, early detection and targets for chemoprevention. It has been previously demonstrated that altered mRNA and proteome signatures of morphologically normal cells bearing a single inhe...
ORGANISM(S): Homo sapiens 
2010-10-21 | E-GEOD-23994 | biostudies-arrayexpress
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