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UnknownOpposing effects of acute versus chronic inhibition of p53 on decitabine's efficacy in myeloid neoplasms.
Not available
S-EPMC6547685 | biostudies-literature
UnknownThe ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1.
Not available
S-EPMC5535027 | biostudies-literature
UnknownASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFβ pathway genes through histone deacetylation.
Not available
S-EPMC6203835 | biostudies-literature
UnknownCRISPR/Cas9-mediated base-editing enables a chain reaction through sequential repair of sgRNA scaffold mutations.
Not available
S-EPMC8668876 | biostudies-literature
TranscriptomicsPrdm16 Knockout Brown Adipose Tissue
Gene expression profile from brown adipose tissues of Prdm16 knockout and wile type mice. Prdm16 is a transcription factor that regulates the thermogenic gene program in brown and beige adipocytes. However, whether Prdm16 is required for the development or physiological function of brown adipose ti...
ORGANISM(S): Mus musculus 
2014-04-09 | E-GEOD-55080 | biostudies-arrayexpress
TranscriptomicsRunx1/Cbfb deficiency effect on MLL-AF9 cells
To identify the target genes of Runx1/Cbfb in MLL fusion leukemia, we performed microarray analysis using control and Runx1/Cbfb-deleted MLL-AF9 cells. c-Kit(+) bone marrow cells derived from Runx1/Cbfb double floxed mice were transduced with MLL-AF9 and CreERT2 (coexpressing Puromycin). After seve...
ORGANISM(S): Mus musculus 
2013-06-30 | E-GEOD-47350 | biostudies-arrayexpress
UnknownAntitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia.
Not available
S-EPMC6814808 | biostudies-literature
TranscriptomicsExpression data from Evi1-transduced primary bone marrow cells
Evi1 is essential for proliferation of hematopoietic stem cells and implicated in the development of myeloid disorders. Particularly, high Evi1 expression defines one of the largest clusters in acute myeloid leukemia and is significantly associated with extremely poor prognosis. Improvement of the t...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-22434 | biostudies-arrayexpress
UnknownHyperactive Natural Killer cells in Rag2 knockout mice inhibit the development of acute myeloid leukemia.
Not available
S-EPMC10739813 | biostudies-literature
UnknownThe conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development.
Not available
S-EPMC7198358 | biostudies-literature
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