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GenomicsThe Histone Methyltransferase Wbp7 Controls Macrophage Function through GPI Glycolipid Anchor Synthesis. [ChIP_seq]
Histone methyltransferases catalyze site-specific deposition of methyl groups, enabling recruitment of transcriptional regulators. In mammals, trimethylation of lysine 4 in histone H3, a modification localized at the transcription start sites of active genes, is catalyzed by six enzymes (SET1a and S...
ORGANISM(S): Mus musculus 
2012-04-09 | E-GEOD-30972 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HepG2 cells overexpressing GPI-phospholipase D vs control sampled at 2 time points
A time course of the effect of overexpressing GPI-PLD on global gene expression in HepG2 cells was compared to control virus. Experiment Overall Design: This experiment compares the global gene expression in HepG2 cells that were either transduced with an adenovirus expressing GPI-phospholipase D or...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4731 | biostudies-arrayexpress
ProteomicsA novel structure of GPI anchored proteins
GPI anchors many proteins to the cell surface. GPI precursor has three mannoses, all of which are modified by ethanolamine-phosphate (EthN-P). It has been believed that EthN-P on the third mannose is always used as a bridge to the protein and EthN-P on the second mannose is removed after GPI is atta...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD021996 | Pride
Human Pigg Gpi anchor Lc-esi- ms 
TranscriptomicsExpression profile of splenocytes with glucose-6-phosphate isomerase (GPI) induced arthritis
To explore TNF-related genes in GPI-induced arthritis, we performed GeneChip analysis using arthritic splenocytes and control-immunized splenocytes. Among the arrayed TNFalpha-related genes, TIARP mRNA was highly expressed in arthritic splenocytes, with levels exceeding more than 20-times the contro...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-17272 | biostudies-arrayexpress
ProteomicsGPI-glycan structures of human Prion from a human brain
To determine glycosylphosphatidylinositol (GPI) structures of human prion proteins isolated from a human brain.
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD017656 | Pride
Gpi Prion Gpi side-chain Brain Human 
TranscriptomicsGPI-anchored Timp1 protein
Tissue inhibitor of metalloproteinase 1 (TIMP-1) controls matrix metalloproteinase (MMP) activity through 1:1 stochiometric binding. Human TIMP-1 fused to a glycosylphosphatidylinositol (GPI) anchor (TIMP-1-GPI) shifts the activity of TIMP-1 from the extracellular matrix to the cell surface. TIMP-1-...
ORGANISM(S): Homo sapiens 
2012-08-23 | E-GEOD-40301 | biostudies-arrayexpress
ProteomicsGPI-glycan structures of human Prion from knock-in mice_LC-MSMS
To determine glycosylphosphatidylinositol (GPI) structures of human prion proteins isolated from knock-in mice those express human prion protein instead of mouse one.
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2020-04-22 | PXD017655 | Pride
Gpi Prion Gpi side-chain Brain Knock-in mouse Human 
ProteomicsGPI-glycan structures of Prion from WT mouse brains
To determine glycosylphosphatidylinositol (GPI) structures of prion proteins isolated from mouse brains.
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD029190 | Pride
Gpi Gpi side chain Prion Brain Mouse 
TranscriptomicsTranscription profiling of mouse GPI-deficient bone marrow cells in a mouse model of targeted Pig-a deletion
Somatic mutation in the X-linked phosphatidylinositol glycan class A (PIG-A) gene causes glycosylphosphatidylinositol (GPI) anchor deficiency in humans with Paroxysmal Nocturnal Hemoglobinuria (PNH). Clinically, patients with PNH have intravascular hemolysis, venous thrombosis and bone marrow failur...
ORGANISM(S): Mus musculus 
2009-09-18 | E-GEOD-14561 | biostudies-arrayexpress
ProteomicsGPI-glycan structures of Prion from PGAP4-KO mouse brains
To determine glycosylphosphatidylinositol (GPI) structures of prion proteins isolated from PGAP4-KO mouse brains.
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD029189 | Pride
Gpi Gpi side chain Prion Brain Mouse 
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