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ProteomicsMolecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq
Muscarinic acetylcholine receptor M3 (M3) and its downstream effector Gq/11 are critical drug development targets given their involvement in numerous physiological processes and diseases. Although a cryo-electron microscopy study previously defined the structure of the M3-miniGq complex, the lack of...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD042562 | Pride
Hdx-ms M3 G protein Gq Gpcr 
ProteomicsOncogenic pathways in uveal melanoma identified by phosphoproteomic analysis
The uveal melanoma cell lines MP41 and MP46 driven by oncogenic G11 (Q209L) and Gq (Q209L), respectively, and a control cell line OCM-1A driven by oncogenic BRAF (V600E) were treated for 24 hours with FR900359, a highly specific inhibitor of Gq/11. Protein extracts were collected and TMT labeled pri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-11 | MSV000090700 | MassIVE
GenomicsExtracellular Succinate Hyperpolarizes M2 Macrophages through SUCNR1/GPR91-Mediated Gq Signaling
Extracellular Succinate Hyperpolarizes M2 Macrophages through SUCNR1/GPR91-Mediated Gq Signaling
PRJNA726262 | ENA
TranscriptomicsPKCzeta-mediated Gaq stimulation of the ERK5 pathway is involved in cardiac hypertrophy
Background: Gq-coupled G protein-coupled receptors (GPCR) mediate the actions of a variety of messengers that are key regulators of cardiovascular function. Enhanced Gaq-mediated signaling plays an important role in cardiac hypertrophy and in the transition to heart failure. We have recently describ...
ORGANISM(S): Mus musculus 
2012-01-10 | E-GEOD-29145 | biostudies-arrayexpress
TranscriptomicsThe Gq/11 family of G alpha subunits is necessary and sufficient for lower jaw development
Development of the vertebrate jaw apparatus depends on highly conserved signaling pathways. Patterning of the lower jaw is driven by Endothelin receptor type A (Ednra) and secreted ligand Endothelin 1 (Edn1). The Ednra signaling pathway establishes the identity of lower jaw progenitors by regulating...
ORGANISM(S): Danio rerio 
2024-09-19 | GSE275013 | GEO
GenomicsThe Gq/11 family of G alpha subunits is necessary and sufficient for lower jaw development
The Gq/11 family of G alpha subunits is necessary and sufficient for lower jaw development
PRJNA1148965 | ENA
UnknownGQ-DNABERT reveals GQ proximal enhancer-promoter interactions associated with tissue-specific transcription.
Not available
S-EPMC12526042 | biostudies-literature
GenomicsSynergistic effect of IL-33 priming and Gq signaling activation in peritoneal cells derived mast cells
Synergistic effect of IL-33 priming and Gq signaling activation in peritoneal cells derived mast cells
PRJNA1098891 | ENA
TranscriptomicsExtracellular Succinate Hyperpolarizes M2 Macrophages through SUCNR1/GPR91-Mediated Gq Signaling
Succinate functions both as a classical TCA cycle metabolite and as an extracellular metabolic stress signal sensed by the mainly Gi-coupled succinate receptor, SUCNR1. In the present study, we characterize and compare effects and signaling pathways activated by succinate and both classes of non-met...
ORGANISM(S): Homo sapiens 
2021-04-30 | GSE173611 | GEO
TranscriptomicsSynergistic effect of IL-33 priming and Gq signaling activation in peritoneal cells derived mast cells
Synergy of signals often causes cells to exhibit stronger physiological responses, especially immune cells. Here we reported that priming of interleukin-33 (IL-33) played a crucial role in the subsequent response of mast cells with Gq signaling. Judging from the levels of cytokines and chemokines, t...
ORGANISM(S): Mus musculus 
2026-03-13 | GSE263664 | GEO
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