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GenomicsThe Stat3/GR interaction code: predictive value of direct/indirect DNA recruitment for transcription outcome
Transcription factor recruitment to genomic sites of action is primarily due to direct protein:DNA interactions. The subsequent recruitment of co-regulatory complexes leads to either transcriptional activation or repression. In contrast to this canonical scheme, some transcription factors such as th...
ORGANISM(S): Mus musculus 
2012-06-06 | E-GEOD-37235 | biostudies-arrayexpress
TranscriptomicsRole of Serine 134 phosphorylation of the glucocorticoid receptor (GR) in glucocorticoid signaling
In response to environmental stressors and a variety of inflammatory cytokines, p38 MAPKs become directly activated. Here we report the human glucocorticoid receptor (GR) Serine 134 as a novel target for p38 MAPK. Unlike most other phosphorylation events that occur on the GR, phosphorylation of Ser1...
ORGANISM(S): Homo sapiens 
2011-10-04 | E-GEOD-28912 | biostudies-arrayexpress
GenomicsCo-activation of GR and NF-kB leads to extensive rearrangemnet of their binding sites and target genes
Global identification of activated GR and p65 binding sites and target genes using ChIP-seq in HeLa B2 cells. generation genome-wide chromatin state-maps of GR, p65 and RNAPII in HeLa B2 cells under conditions 1) DMSO (control); 2) TA 1M-BM-5M 4hr; 3) TNFM-NM-1 10ng/ml ; 4) TA 1M-BM-5M 4hr at at th...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-24518 | biostudies-arrayexpress
TranscriptomicsGlucocorticoid and androgen receptor profiling (ChIP-seq) in U2OS-GR and U2OS-AR cells upon hormone treatment
We performed ChIP-seq targeting the glucocorticoid receptor (GR) in the U2OS-GR cell line and the androgen receptor (AR) in the U2OS-AR cell line. The cell lines are derived from U2OS ATTC:HTB-96 and stably transfected with an expression construct for either rat GR or human AR, respectively. The U2O...
ORGANISM(S): Homo sapiens 
2021-03-09 | E-MTAB-9616 | biostudies-arrayexpress
TranscriptomicsA1-2 expression analysis of GR activation
A1-2 cells treated with 100 nM Dexamethasone or ethanol vehicle for 8h. The ability of steroid hormone receptors to initiate a genetic program is tightly regulated by the chromatin environment of the responsive regions. Using the glucocorticoid receptor (GR) as a model factor for transcriptional in...
ORGANISM(S): Homo sapiens 
2012-02-28 | E-GEOD-30592 | biostudies-arrayexpress
GenomicsRhodoferax aquaticus strain:Gr-4
Rhodoferax aquaticus strain:Gr-4 Genome sequencing
PRJNA522675 | ENA
GenomicsLimosilactobacillus fermentum strain:GR-9
Limosilactobacillus fermentum strain:GR-9 Genome sequencing
PRJNA1232399 | ENA
GenomicsPediococcus acidilactici strain:GR-5
Pediococcus acidilactici strain:GR-5 Genome sequencing
PRJNA1207065 | ENA
GenomicsLacticaseibacillus rhamnosus strain:GR-1
Lacticaseibacillus rhamnosus strain:GR-1 Genome sequencing and assembly
PRJNA417224 | ENA
GenomicsCreation of an anti-inflammatory GR cistrome by TLR4 signaling
An unresolved molecular paradox is how the glucocorticoid receptor (GR) activates some genes while potently repressing others. We carried out genome-wide localization and expression profiling experiments in primary bone marrow-derived mouse macrophages treated with Dexamethasone in the presence or a...
ORGANISM(S): Mus musculus 
2012-12-04 | E-GEOD-31796 | biostudies-arrayexpress
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