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TranscriptomicsGene expression analyses of hematopoietic stem cell (HSC) subsets in wildtype or CD41-KO mice
The hematopoietic stem cell (HSC) compartment is heterogeneous, yet our understanding of the identities of different HSC subtypes is limited. Here we show that platelet integrin CD41 (M-NM-1IIb), currently thought to only transiently mark fetal HSCs, is expressed on an adult HSC subtype that accumul...
ORGANISM(S): Mus musculus 
2013-04-11 | E-GEOD-45561 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of elicitor treatment over time (0, 30, 60 min) in Arabidopsis Landsberg (wt) and fls2-17 (flagellin receptor mutant)
Transcriptional changes upon elicitor treatment over time (0, 30, 60 min) have been analysed with the A.thaliana Landsberg (wt) and fls2-17 (flagellin receptor mutant).
ORGANISM(S): Arabidopsis thaliana 
2006-03-15 | E-MEXP-547 | biostudies-arrayexpress
TranscriptomicsReprogramming of a B cell line into macrophages
Transcription factor induced reprogramming of one specialized cell type into another is a promising approach for regenerative medicine. However, the process still remains poorly understood, in large part because of the lack of adequate experimental models. Here we describe a robust cell reprogrammin...
ORGANISM(S): Mus musculus 
2009-11-22 | E-GEOD-17316 | biostudies-arrayexpress
ProteomicsProteome analysis of skeletal muscle samples from a porcine model of Duchenne muscular dystrophy treated by somatic gene editing
Duchenne muscular dystrophy (DMD) is caused by genetic deficiency of dystrophin and characterized by massive structural and functional changes of skeletal muscle tissue, leading to terminal muscle failure. In this project, proteomics data from skeletal muscle of a genetically engineered DMD pig mode...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2020-02-05 | PXD014893 | Pride
Porcine model Duchenne muscular dystrophy Somatic gene editing 
UnknownBCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells
Not available
S-SCDT-10_15252-EMBJ_2023113448 | biostudies-other
UnknownDimensionality of the reinforced superconductivity in UTe<sub>2</sub>.
Not available
S-EPMC12638786 | biostudies-literature
TranscriptomicsOvercoming the stochastic phase of iPS cells reprogramming by a pulse of C/EBPα [array]
Somatic cell reprogramming into pluripotent stem cells induced by Oct4, Sox2, Klf4 and Myc (OSKM) occurs at low frequencies and with a considerable delay involving a stochastic phase. In contrast, transdifferentiation of B cells into macrophages induced by C/EBPα is fully efficient and initiated al...
ORGANISM(S): Mus musculus 
2013-11-17 | E-GEOD-46321 | biostudies-arrayexpress
TranscriptomicsHow C/EBPa creates an elite cell state for reprogramming to pluripotency [RNAseq]
Mouse Bcell, upon ectopic expression of the transcription factor Cebpa for 18h, can be reprogrammed to iPS with extremely high efficiency. To understand the molecular control of this phenomena we performed multiple high throughtput functionnal genomic analysis. Transcriptomic by RNAseqencing (polyA+...
ORGANISM(S): Mus musculus 
2016-02-19 | E-GEOD-71217 | biostudies-arrayexpress
GenomicsHow C/EBPa creates an elite cell state for reprogramming to pluripotency [ChIPseq]
Mouse Bcell, upon ectopic expression of the transcription factor Cebpa for 18h, can be reprogrammed to iPS with extremely high efficiency. To understand the molecular control of this phenomena we performed multiple high throughtput functionnal genomic analysis. Genome binding/occupancy of transcript...
ORGANISM(S): Mus musculus 
2016-02-19 | E-GEOD-71215 | biostudies-arrayexpress
TranscriptomicsC/EBP? poises B cells for rapid reprogramming into iPS cells [RNA-Seq]
C/EBP? induces transdifferentiation of B cells into macrophages at high efficiencies and enhances reprogramming into induced pluripotent stem cells (iPSCs) when co-expressed with Oct4, Sox2, Klf4 and Myc (OSKM). However, how C/EBP? accomplishes these effects is unclear. We now found that transient C...
ORGANISM(S): Mus musculus 
2013-11-17 | E-GEOD-52396 | biostudies-arrayexpress
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