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ProteomicsAn Outer Membrane Protein-Targeting Antibiotic Against Resistant Gram-Negative Bacterial Pathogens
There is an urgent need for novel antibiotics against carbapenem and 3rd generation cephalosporin-resistant Gram-negative pathogens, for which the last-resort antibiotics have lost most of their efficacy. We describe here a novel class of synthetic antibiotics that was inspired from natural product-...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2020-02-04 | MSV000084899 | MassIVE
TranscriptomicsGene expression response to bacterial phagocytosis by S2 cells (control and eater RNAi knock down)
The Drosophila phagocytic receptor Eater is expressed specifically in phagocytic hemocytes. It contributes to host immune defense and is required for survival of bacterial infections. Eater is involved in recognition and phagocytosis of bacteria. We used microarrays to determine whether any gene exp...
ORGANISM(S): Drosophila melanogaster 
2011-08-24 | E-GEOD-31564 | biostudies-arrayexpress
MetabolomicsMetabolic Rewiring of Bacterial Subpopulations Governs Polymyxin Responses in Acinetobacter baumannii
Polymyxins are often last-resort antibiotics against high-priority Gram-negative pathogens, particularly Acinetobacter baumannii. However, most mechanistic studies to date have overlooked the heterogeneity within bacterial populations during polymyxin treatment. Using time-lapse imaging and propidiu...
2026-07-27 | MTBLS14745 | MetaboLights
TranscriptomicsCirculating miRNA expression after subcutaneous injection of Gram negative and positive bacteria in the mice
To explore the circulating miRNA expression after subcutaneous injection of Gram negative and positive bacteria in the mice The recombinant specific Gram negative pathogens Escherichia coli (xen14) and Gram positive pathogens Staphyllococcus aureus (xen29) were purchased from the Caliper (Caliper, P...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-49189 | biostudies-arrayexpress
ProteomicsAn Outer Membrane Protein-Targeting Antibiotic Against Resistant Gram-Negative Bacterial Pathogens
There is an urgent need for novel antibiotics against carbapenem and 3rd generation cephalosporin-resistant Gram-negative pathogens, for which the last-resort antibiotics have lost most of their efficacy. We describe here a novel class of synthetic antibiotics that was inspired from natural product-...
ORGANISM(S): Escherichia coli 
2019-10-22 | PXD010174 | Pride
Macrocyclic peptidomimetic antibiotics Novel molecular mode of action Lpt complex E.coli Dda Ompta (outer membrane-targeting antibiotics) Lc-ms/ms Bam complex Photoaffinity labeling Thermo q-exactive plus Interaction mapping Photo crosslinking Gram-negative eskape pathogens 
GenomicsDevelopment and Characterization of Bacteriophage Cocktails targeting Gram-Negative ESKAPE Pathogens
Development and Characterization of Bacteriophage Cocktails targeting Gram-Negative ESKAPE Pathogens
PRJEB123093 | ENA
TranscriptomicsREG3γ-deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum
Objective: Reg3g has been proposed to have a protective role against infection due to its bactericidal effect on Gram-positive bacteria, but evidence from in vivo studies is lacking. Therefore we generated a Reg3g-/- mouse, to determine its role in intestinal homeostasis and protection against exper...
ORGANISM(S): Mus musculus 
2014-06-06 | E-GEOD-44409 | biostudies-arrayexpress
GenomicsGram Negative Carbapenemase Detection Genome sequencing and assembly
Gram Negative Carbapenemase Detection Genome sequencing and assembly
PRJNA292904 | ENA
GenomicsGram-Negative Enterobacterales in Mali
Gram-Negative Enterobacterales from Paediatric Infections, Mali (2005-2023)"
PRJEB87282 | ENA
UnknownNovel antimony-based antimicrobial drug targets membranes of Gram-positive and Gram-negative bacterial pathogens.
Not available
S-EPMC11237720 | biostudies-literature
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