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MetabolomicsAndrogens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome-LC-MS analysis of granulosa cells

Polycystic ovary syndrome (PCOS) is the primary cause of female infertility. Growing evidence suggests that dysregulation of amino acid metabolism plays a significant role in the onset and progression of PCOS. However, the underlying mechanism remains unclear. In this study, we conducted targeted...

2025-04-14 | MTBLS12367 | MetaboLights
Transcriptomicsgranulosa cell tumor vs normal granulosa cells
mRNA expression profiling in human granulosa cell tumor cell line and normal granulosa cells
ORGANISM(S): Homo sapiens 
2012-01-26 | E-MTAB-957 | biostudies-arrayexpress
TranscriptomicsRhesus monkey cumulus cells revert to a mural granulosa cell state following an ovulatory stimulus
Follicular somatic cells (mural granulosa cells and cumulus cells) and the oocyte communicate through paracrine interactions and through direct gap junctions between oocyte and cumulus cells. Considering that mural and cumulus cells arise through a common developmental pathway and that their differe...
ORGANISM(S): Macaca mulatta 
2012-10-04 | E-GEOD-38387 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat periovulatory granulosa cells treated with Org 31710 in vitro
Transcriptional effects of Org 31710 in rat periovulatory granulosa cells in vitro
ORGANISM(S): Rattus norvegicus 
2009-10-02 | E-MEXP-1974 | biostudies-arrayexpress
TranscriptomicsLaser Capture Microdissection isolation of preovulatory granulosa cells from WT and bERKO ovaries
Determining the spatial and temporal expression of genes involved in the ovulatory pathway is critical for the understanding of the role of each estrogen receptor in the modulation of folliculogenesis and ovulation. Estrogen receptor (ER) b is highly expressed in ovarian granulosa cells and mice lac...
ORGANISM(S): Mus musculus 
2013-07-03 | E-GEOD-44651 | biostudies-arrayexpress
TranscriptomicsThe ISWI ATPase Snf2L is required for superovulation and regulates Fgl2 in differentiating mouse granulosa cells
We investigate the role of Snf2l in ovaries by characterizing a mouse bearing an inactivating deletion on the ATPase domain of Snf2l (Ex6DEL). Snf2l mutant mice produce significantly fewer eggs than control mice when superovulated. Thus, gonadotropin stimulation leads to a significant deficit in sec...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-42997 | biostudies-arrayexpress
TranscriptomicsFOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development
The Forkhead Box, FOXO1 and FOXO3, transcription factors regulate multiple functions in mammalian cells. Selective inactivation of the Foxo1 and Foxo3 genes in murine ovarian granulosa cells severely impairs follicular development and apoptosis causing infertility, and as shown herein, granulosa cel...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-67662 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat and mouse granulosa cells infected with adenoviral vectors expressing two FOXO1 mutants reveals FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells
The forkhead box transcription factor FOXO1 is highly expressed in granulosa cells of growing follicles but is down-regulated by FSH in culture or by LH-induced luteinization in vivo. To analyze the function of FOXO1, we infected rat and mouse granulosa cells with adenoviral vectors expressing two F...
ORGANISM(S): Rattus norvegicus 
2009-04-25 | E-GEOD-15727 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of controlled ovarian hyperstimulation in human granulosa cells
The objective of this study was to investigate the differences in the gene expression profile of the granulosa cells from preovulatory follicles obtained after controlled ovarian hyperstimulation (COH) with either recombinant FSH (rFSH) or urine derived human menopausal gonadotropins (hMG).
ORGANISM(S): Homo sapiens 
2008-01-31 | E-MEXP-1238 | biostudies-arrayexpress
TranscriptomicsOvarian granulosa cell tumor and normal granulosa cells transcriptomes
RNA was extracted from normal human granulosa cells from IVF patients (hGC1 and hGC2 samples) and from adult-type ovarian granulosa cell tumor samples (H1, H8, H20, H23, H24, H28, H30, H33, H4, H18) as described in Jamieson et al, 2010. RNA from all samples was linearly amplified using the Whole Tra...
ORGANISM(S): Homo sapiens 
2012-08-02 | E-MTAB-483 | biostudies-arrayexpress
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