Sort   by:  
 Page size 
TranscriptomicsPTEN loss deM-oM-,M-^Anes a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) represents a heterogeneous diagnostic category with distinct molecular subtypes that can be deM-oM-,M-^Aned by gene expression proM-oM-,M-^Aling. However, even within these deM-oM-,M-^Aned subtypes, heterogeneity prevails. To further elucidate the pathogenesis o...
ORGANISM(S): Homo sapiens 
2013-07-09 | E-GEOD-45495 | biostudies-arrayexpress
TranscriptomicsMCL1 is deregulated in subgroups of diffuse large B-cell lymphoma
MCL1 is an anti-apoptotic member of the BCL2 family that is deregulated in various solid and hematological malignancies. However, its role in the molecular pathogenesis of diffuse large B-cell lymphoma (DLBCL) is unclear. We analyzed gene expression profiling data from 350 DLBCL patient samples and ...
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-43272 | biostudies-arrayexpress
TranscriptomicsEssential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma survival
Three ALCL cell lines DEL, FEPD and K299 were induced with an IRF4-specific shRNA for up to 96 hours. The three ALCL cell lines DEL, FEPD and K299 were induced with an IRF4-specific shRNA for four durations and compared with the corresponding not-induced control.
ORGANISM(S): Homo sapiens 
2015-01-03 | E-GEOD-59747 | biostudies-arrayexpress
TranscriptomicsGEP of PMBCs during treatment with a gene-modified allogeneic tumor cell vaccine in advanced renal cell cancer (RCC) patients
Tumor-induced immunosuppression remains a major challenge for immunotherapy of cancer patients. To further elucidate why an allogeneic gene-modified (Interleukin-7(IL-7)/CD80 co-transfected) renal cell cancer vaccine failed to induce clinically relevant TH1-polarized immune responses, peripheral blo...
ORGANISM(S): Homo sapiens 
2014-09-24 | E-GEOD-51490 | biostudies-arrayexpress
TranscriptomicsIkB-like protein NFKBIZ regulates NF-kB signaling and is critical for survival of ABC DLBCL
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-46974 | biostudies-arrayexpress
TranscriptomicsIkB-like protein NFKBIZ regulates NF-kB signaling and is critical for survival of ABC DLBCL (MLN inhibition)
Constitutive activation of the nuclear factor-kappa B (NF-kB) pathway is a hallmark of the activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL). Recurrent mutations of NF-kB regulators that cause constitutive activity of this oncogenic pathway have been identified. However, i...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-46972 | biostudies-arrayexpress
TranscriptomicsExpression data from treatment-induced senescence in mouse Emu-myc B-cell lymphoma model
Treatment induced senescence (TIS) is a terminal cell cycle arrest program, increasingly recognized as a tumor suppressor mechanism complementing apoptosis in response to standard chemotherapy regimens. In particular cells with blocked apoptotic pathways rely on senescence as the only remaining fail...
ORGANISM(S): Mus musculus 
2011-11-21 | E-GEOD-31099 | biostudies-arrayexpress
UnknownChromatin loops are an ancestral hallmark of the animal regulatory genome.
Not available
S-EPMC12221973 | biostudies-literature
UnknownStratified analyses refine association between TLR7 rare variants and severe COVID-19.
Not available
S-EPMC11320601 | biostudies-literature
UnknownCommon, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.
Not available
S-EPMC8661833 | biostudies-literature
Sort   by:  
 Page size