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TranscriptomicsMicroarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer’s disease
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that threatens to reach epidemic proportions as our population ages. Although much research has examined molecular pathways associated with AD, relatively few studies have focused on critical early stages. Our prior microarray stud...
ORGANISM(S): Homo sapiens 
2011-07-31 | E-GEOD-28146 | biostudies-arrayexpress
TranscriptomicsGene Expression in the Rice Blast Fungus, Magnaporthe grisea, During Nitrogen Starvation
This experiment was designed to analyze transcriptional changes that occur when the fungal plant pathogen M. grisea is shifted from a complete media to a nitrogen-starved media. Comparisons were made in the following way between fungal mycelial grown in minimal media supplemented with a nitrogen sou...
ORGANISM(S): Magnaporthe grisea 
2010-07-01 | E-GEOD-2716 | biostudies-arrayexpress
UnknownDiscovery of electrophilic degraders that exploit SNAr chemistry.
Not available
S-EPMC11463635 | biostudies-literature
UnknownPurinergic System Transcript Changes in the Dorsolateral Prefrontal Cortex in Suicide and Major Depressive Disorder.
Not available
S-EPMC11898938 | biostudies-literature
ProteomicsDiscovery of covalent CDK14 inhibitors with pan-TAIRE family specificity
Cyclin dependent kinase 14 (CDK14) and other TAIRE family kinases (CDKs 15-18) are proteins that lack functional annotation but are frequent off-targets of clinical kinase inhibitors. In this study we develop and characterize FMF-04-159-2, the first tool compound that specifically targets CDK14 cova...
ORGANISM(S): Homo sapiens (Human) 
2019-03-29 | PXD012692 | Pride
Covalent inhibitor Druggable genome Mitosis Taire kinase Cell-cycle Cdk14 
TranscriptomicsDNA methylation profiles of human brain tissue samples
The main goal of the study was to measure the epigenetic age (also known as DNA methylation age) of human tissues and to relate it to chronological age. Toward this end, we used the epigenetic clock software described in Horvath S (n=2013) DNA methylation age of human tissues and cell types. Genome ...
ORGANISM(S): Homo sapiens 
2015-06-03 | E-GEOD-64509 | biostudies-arrayexpress
UnknownGSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor.
Not available
S-EPMC4208292 | biostudies-literature
UnknownExploring Ligand-Directed N-Acyl-N-alkylsulfonamide-Based Acylation Chemistry for Potential Targeted Degrader Development.
Not available
S-EPMC8366001 | biostudies-literature
UnknownClinical efficacy of bioactive restorative materials in controlling secondary caries: a systematic review and network meta-analysis.
Not available
S-EPMC10268411 | biostudies-literature
UnknownDistributed Medical Education (DME) in psychiatry: perspectives on facilitators, obstacles, and factors affecting psychiatrists' willingness to engage in teaching activities.
Not available
S-EPMC10895840 | biostudies-literature
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