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ProteomicsDesign and Development of DNA Damage Chemical Inducers of Proximity (DD-CIP) for Targeted Cancer Therapy
Many chemotherapies are effective against cancers that display high levels of genome instability by disrupting or overwhelming the DNA damage response to induce cell death. PARP inhibitors (PARPi) exploit this vulnerability by stalling DNA repair particularly in homologous recombination (HR)-deficie...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-12-06 | MSV000100135 | MassIVE
ProteomicsDiscovery of covalent CDK14 inhibitors with pan-TAIRE family specificity
Cyclin dependent kinase 14 (CDK14) and other TAIRE family kinases (CDKs 15-18) are proteins that lack functional annotation but are frequent off-targets of clinical kinase inhibitors. In this study we develop and characterize FMF-04-159-2, the first tool compound that specifically targets CDK14 cova...
ORGANISM(S): Homo sapiens (Human) 
2019-03-29 | PXD012692 | Pride
Covalent inhibitor Druggable genome Mitosis Taire kinase Cell-cycle Cdk14 
ProteomicsRelocalizing transcriptional kinases to activate apoptosis_Proteomics Data
Kinases are critical regulators of cellular function that are commonly implicated in the mechanisms underlying disease. Most drugs that target kinases are molecules that inhibit their catalytic activity, but here we used chemically induced proximity to convert kinase inhibitors into activators of th...
ORGANISM(S): Homo sapiens (Human) 
2024-12-20 | PXD051502 | Pride
Cancer Lymphoma Transcription Kinase 
TranscriptomicsA unifying model for mTORC1-mediated regulation of mRNA translation
Ribsome profiling analysis of mRNA translation in mouse cells under conditions of mTOR activiation or inhibition. embryonic fibroblasts from 4EBP1/2 p53 mutants treated with Torin1
ORGANISM(S): Mus musculus 
2012-05-02 | E-GEOD-36892 | biostudies-arrayexpress
ProteomicsMudPIT analysis of STRN4 interacting proteins from HEK TER cells expressing either SV40 ST or GFP
HEK TER cells expressing either SV40 ST or GFP (30 x 15-cm diameter plates) were harvested with lysis buffer (20 mM imidazole HCl, 2 mM EDTA, 2 mM EGTA, pH 7.0 with 10 ug/mL each of aprotinin, leupeptin, pepstatin, 1 mM benzamidine, and 1 mM PMSF). The clarified cell extract was incubated overnight ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-12-05 | MSV000084662 | MassIVE
ProteomicsEffect of Kinase Inhibitors on Intraerythrocytic Plasmodium falciparum Phosphoproteome
Three flasks of asynchronous blood stage P. falciparum Dd2 culture were grown to ~15% parasitemia, 4% hematocrit using the Trager- Jensen method. Per biological replicate, parasites were treated with 5 x EC50 or EC90 of compound depending on the slope of the EC50 curve for 3 hours. Compounds are DC-...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Plasmodium Falciparum Dd2 (ncbitaxon:57267) 
2023-04-03 | MSV000091619 | MassIVE
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