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TranscriptomicsLoss of DNA replication control is a potent initiator of gene amplification
Eukaryotic cells use numerous mechanisms to ensure that no segment of their DNA is re-replicated within a single cell cycle. Despite longstanding speculation that such tight regulation is needed to protect cells from genomic alterations, this notion has never been experimentally tested. Here we show...
ORGANISM(S): Saccharomyces cerevisiae 
2011-05-17 | E-GEOD-22018 | biostudies-arrayexpress
TranscriptomicsMicroarray profiling, C elegans: Neuronal miRISC IP vs Total RNA
Identifying the physiological functions of microRNAs (miRNAs) is often challenging because miRNAs commonly impact gene expression under specific physiological conditions through complex miRNA::mRNA interaction networks and in coordination with other means of gene regulation, such as transcriptional ...
ORGANISM(S): Caenorhabditis elegans 
2014-01-01 | E-GEOD-45871 | biostudies-arrayexpress
TranscriptomicssiRNA knockdown of ribosomal protein gene RPL19 abrogates the aggressive phenotype of human prostate cancer
Ribosomal protein RPL19 is an integral component of eukaryotic ribosomes and universally involved in protein synthesis. Although consistently stableM-BM- in normal cells, RPL19 transcription is relatively elevated in prostate cancer. Using siRNA, we inhibited RPL19 transcription and demonstrated th...
ORGANISM(S): Homo sapiens 
2011-12-08 | E-GEOD-26774 | biostudies-arrayexpress
TranscriptomicsMolecular Basis of Renal Adaptation in a Murine Model of Congenital Obstructive Nephropathy
Congenital obstructive nephropathy is a common cause of chronic kidney disease and a leading indication for renal transplant in children. The cellular and molecular responses of the kidney to congenital obstruction are incompletely characterized. In this study, we evaluated global transcription in k...
ORGANISM(S): Mus musculus 
2013-06-18 | E-GEOD-48041 | biostudies-arrayexpress
UnknownOptimization of Metformin in the GRADE Cohort: Effect on Glycemia and Body Weight.
Not available
S-EPMC7171946 | biostudies-literature
UnknownGenetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
Not available
S-EPMC6463297 | biostudies-literature
UnknownOutcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study.
Not available
S-EPMC8634634 | biostudies-literature
UnknownDeath following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.
Not available
S-EPMC10364875 | biostudies-literature
UnknownMachine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score.
Not available
S-EPMC8344569 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
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