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ProteomicsAn early, novel arginine methylation of KCa3.1 attenuates subsequent T cell exhaustion.
We identified changes in the protein arginine methylome during the initial 30 min of TCR engagement and discovered a novel arginine methylation of a Ca2+ -activated potassium transporter, KCa3.1, which regulates Ca2+ -mediated NFAT1 signaling to ensure optimal activation.
ORGANISM(S): Mus musculus (Mouse) 
2025-05-29 | PXD064423 | Pride
Arginine Protein Methylome 
TranscriptomicsHIF1a-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
Upon antigen stimulation, the bioenergetic demands of T cells increase dramatically over the resting state. Although a role for the metabolic switch to glycolysis has been suggested to support increased anabolic activities and facilitate T cell growth and proliferation, whether cellular metabolism c...
ORGANISM(S): Mus musculus 
2011-06-07 | E-GEOD-29765 | biostudies-arrayexpress
TranscriptomicsSensory ray genes
These experiments were undertaken with the goal of identifying genes whose expression is enriched in or restricted to the sensory rays of the C. elegans male tail. We constructed two mutant strains in which ray development is either compromised (EM672) or enhanced (EM673), and harvested mRNA from ad...
ORGANISM(S): Caenorhabditis elegans 
2006-01-05 | E-GEOD-3979 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of response of Buchnera aphidicola to depletion of essential amino acids combined with an increase in sucrose in the diet of its aphid host
The aim of this work was to analyze the transcriptomic response of Buchnera aphidicola when the aphid host is submitted to depletion in essential amino acids (EAA). This treatment was combined with an increase in sucrose concentration to influence the bacterial growth rate. In this experiment, the d...
ORGANISM(S): Buchnera aphidicola 
2006-04-03 | E-TABM-85 | biostudies-arrayexpress
TranscriptomicsGene expression in helped versus helpless CD8 T cells
CD4+ ‘helper’ T cells (TH) are pivotal for the generation and maintenance of CD8+ T cell responses. ‘Helped’ CD8+ T cells receive signals during priming that prevent the induction of the pro-apoptotic molecule TRAIL during reactivation, thereby enabling robust secondary expansion. Conversely, ‘helpl...
ORGANISM(S): Mus musculus 
2011-11-26 | E-GEOD-33862 | biostudies-arrayexpress
Genomicsc-Myc is a universal amplifier of gene expression
This SuperSeries is composed of the following subset Series: GSE37222: c-Myc is a universal amplifier of gene expression [Microarray] GSE37229: c-Myc is a universal amplifier of gene expression [ChIP-Seq] Refer to individual Series
ORGANISM(S): Mus musculus 
2012-09-27 | E-GEOD-37230 | biostudies-arrayexpress
Genomicsc-Myc is a universal amplifier of gene expression [ChIP-Seq]
The c-Myc HLH-bZIP protein has been implicated in physiological or pathological growth, proliferation, apoptosis, metabolism and differentiation at the cellular, tissue or organismal levels via regulation of numerous target genes. In part due to the incomplete inventory and functional accounting of ...
ORGANISM(S): Mus musculus 
2012-09-27 | E-GEOD-37229 | biostudies-arrayexpress
TranscriptomicsOntogeny of CD24 expression in the human fetal kidney
CD24, or heat stable antigen, is a cell surface sialoglycoprotein expressed on immature cells that disappears after the cells have reached their final differentiation stage. CD24 may be important in human embryonic kidney epithelial cell differentiation. In mice, CD24 expression is up-regulated in t...
ORGANISM(S): Homo sapiens 
2009-11-11 | E-GEOD-18969 | biostudies-arrayexpress
TranscriptomicsDiet Synergistically Affects Helicobacter pylori-Induced Gastric Carcinogenesis in Nonhuman Primates
BACKGROUND & AIMS: Gastric cancer results from a combination of Helicobacter pylori (H pylori) infection, exposure to dietary carcinogens, and predisposing genetic make-up. Because the role of these factors in gastric carcinogenesis cannot be determined readily in human beings, the present study exa...
ORGANISM(S): Macaca mulatta 
2009-10-07 | E-GEOD-18434 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from hypothyroid mice pups produced from dams given 6-propyl-2-thiouracil (PTU) in their drinking water
Pregnant dams were treated with 0.1% or 0.04% 6-propyl-2-thiouracil (PTU) in drinking water continuously from day 13 post conception until weaning to produce hypothyroid pups. livers were collected from vehicle and 0.1% PTU treated pups at post-natal day (PND) 15 and mRNA from these was subjected to...
ORGANISM(S): Mus musculus 
2007-05-03 | E-MEXP-1091 | biostudies-arrayexpress
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