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MetabolomicsThe ULK3 kinase is a key determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic implications. We show that ULK3 is a nuclear kinase with elevated expression levels in squamous cell carcinomas (SCCs) arising in multiple body sites,...
2022-11-14 | MTBLS5155 | MetaboLights
ProteomicsAn early, novel arginine methylation of KCa3.1 attenuates subsequent T cell exhaustion.
We identified changes in the protein arginine methylome during the initial 30 min of TCR engagement and discovered a novel arginine methylation of a Ca2+ -activated potassium transporter, KCa3.1, which regulates Ca2+ -mediated NFAT1 signaling to ensure optimal activation.
ORGANISM(S): Mus musculus (Mouse) 
2025-05-29 | PXD064423 | Pride
Arginine Protein Methylome 
TranscriptomicsDNA binding factors shape the mouse methylome at distal regulatory regions.
This SuperSeries is composed of the following subset Series: GSE30202: DNA binding factors shape the mouse methylome at distal regulatory regions [BIS_seq] GSE30203: DNA binding factors shape the mouse methylome at distal regulatory regions [ChIP-seq] GSE30204: DNA binding factors shape the mouse me...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-30206 | biostudies-arrayexpress
TranscriptomicsMethylome-wide comparison of human genomic DNA extracted from whole blood and from EBV-transformed lymphocyte cell lines
DNA from Epstein-Barr virus (EBV)-transformed lymphocyte cell lines (LCLs) has proven very useful for studies of genetic sequence polymorphisms. Whether EBV-LCL DNA is suitable for methylation studies is less clear. We conduct a genome-wide methylation investigation using an array set with 45 millio...
ORGANISM(S): Homo sapiens 
2012-03-08 | E-GEOD-35204 | biostudies-arrayexpress
GenomicsThe DNA methylome of human peripheral blood mononuclear cells
DNA methylation plays a vital role in genome dynamics and, in the human genome, occurs predominantly at cytosine guanine dinucleotide (CpG) sites. The diploid haploid human genome analysed here contains around 2060 million CpG sites (methylome) where DNA methylation can vary, affecting many biologic...
ORGANISM(S): Homo sapiens 
2010-09-04 | E-GEOD-17972 | biostudies-arrayexpress
GenomicsComparative DNA methylome analysis of endometrioid adenocarcinoma, uterine papillary serous carcinoma, and normal endometrium
Classically, there are two types of endometrial cancer, endometrioid adenocarcinoma (EAC), or Type I; and uterine papillary serous carcinoma (UPSC), or Type II. These two types of cancers exhibit distinct DNA methylation levels in promoters of many genes. In EAC, many tumor suppressor genes were sil...
ORGANISM(S): Homo sapiens 
2014-10-12 | E-GEOD-51565 | biostudies-arrayexpress
TranscriptomicsEndometrial methylome of patients without endometriosis
Alterations in endometrial DNA methylation profile have been proposed as one potential mechanism initiating the development of endometriosis. However, the normal endometrial methylome is influenced by the cyclic hormonal changes and the menstrual cycle phase-dependent epigenetic signature should be ...
ORGANISM(S): Homo sapiens 
2016-02-15 | E-GEOD-73949 | biostudies-arrayexpress
TranscriptomicsSperm but not oocyte DNA methylome is inherited by zebrafish early embyros
5-methylcytosine is a major epigenetic modification sometimes called "the fifth nucleotide". However, our knowledge of how offspring inherit the DNA methylome from parents is limited. We generated nine single-base resolution DNA methylomes including zebrafish gametes and early embryos. The...
ORGANISM(S): Danio rerio 
2013-05-20 | E-GEOD-44075 | biostudies-arrayexpress
TranscriptomicsIntegration of transcriptome and methylome analyses to dissect molecular pathogenesis of primary aldosteronism: comparision between aldosterone-producing adenomas and adjacent adrenal glands [methylome]
Primary aldosteronism (PA) is the most common endocrine hypertension comprising 10% of hypertensive patients. A recent series of transcriptome analyses using DNA microarray has shown that neumerous genes are differentially expressed between aldosterone-producing adenoma (APA) and its adjacent adrena...
ORGANISM(S): Homo sapiens 
2015-05-09 | E-GEOD-60043 | biostudies-arrayexpress
Proteomicsm5C methylome, transcriptome and proteome of sysnechocystis
m5C methylome, transcriptome and proteome of sysnechocystis
ORGANISM(S): Synechocystis Sp. Pcc 6803 
PXD055431 |
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