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TranscriptomicsExpression analysis of African Green Monkeys after treatment with a miR-33a/b-targeting LNA-antimiR
Investigation of whole genome gene expression level changes in African Green Monkeys treated with antimiR-33a/b, compared to the animal treated with vehicle The treatment of the monkeys is further described in Rottiers V, Obad S, McGarrah R, Black JC, Lindholm M, Goody R, Lawrence M, Whetstine JR, G...
ORGANISM(S): Chlorocebus aethiops 
2013-08-23 | E-GEOD-50116 | biostudies-arrayexpress
MetabolomicsA metabolic dependency for host isoprenoids in the obligate intracellular pathogen Rickettsia parkeri underlies a sensitivity for the statin class of host-targeted therapeutics
Gram-negative bacteria in the order Rickettsiales are obligate intracellular parasites that cause human diseases such typhus and spotted fever. They have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence of extensive genome streamlining. However, it rema...
2019-10-31 | MTBLS846 | MetaboLights
ProteomicsSIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion
Sirtuins are NAD+-dependent protein deacylases that regulate several aspects of metabolism and aging. In contrast to the other mammalian sirtuins, the primary enzymatic activity of mitochondrial sirtuin 4 (SIRT4) and its overall role in metabolic control has remained enigmatic. Using a combination o...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-05 | PXD005896 | Pride
Protein acylation Insulin secretion Leucine metabolism Sirt4 
MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
TranscriptomicsEffect of ppGpp on Salmonella Typhimurium gene expression
The expression profile of an S. Typhimurium mutant strain unable to synthesise ppGpp (relAspoT deletions) was compared to the wild-type strain. The effect of ppGpp on virulence gene expression was studied under 4 different growth conditions that induce virulence gene expression. Keywords: genetic mo...
ORGANISM(S): Salmonella typhimurium 
2010-06-11 | E-GEOD-4631 | biostudies-arrayexpress
MetabolomicsMetabolic phenotyping of urine from a dementia research cohort
To better understand the molecular mechanisms underpinning physiological variation in human populations, metabolic phenotyping approaches are increasingly being applied to studies involving hundreds and thousands of biofluid samples. Hyphenated ultra-performance liquid chromatography-mass spectromet...
2022-03-01 | MTBLS719 | MetaboLights
ModelsTFInfer: a tool for probabilistic inference of transcription factor activities
TFInfer: a tool for probabilistic inference of transcription factor activities
2013-01-14 | 102 | FAIRDOMHub
TranscriptomicsTranscriptomic profiling of Salmonella during lag, exponential and stationary phases of growth
Transcriptional profiles during all phases of growth of Salmonella Typhimurium SL1344 were obtained and used to investigate growth phase-dependent alterations in gene expression. Viable count growth curve analysis of the growth system showed a culture lag time of 2.09 hours, and profiles at 4, 20, 4...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 
2011-12-13 | E-GEOD-22294 | biostudies-arrayexpress
ModelsA Mathematical Model of Metabolism and Regulation Provides a Systems-Level View of the Oxygen Response of Escherichia coli
A Mathematical Model of Metabolism and Regulation Provides a Systems-Level View of the Oxygen Response of Escherichia coli
2014-03-18 | 23 | FAIRDOMHub
GenomicsATD
WTCCC1 project Autoimmune Thyroid Disease (ATD) samples
EGAD00000000011 | EGA
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