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MetabolomicsSubcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of multidrug therapy. Difficulty visualizing the subcellular localization of antibiotics in infected host cells means t...
2020-12-07 | MTBLS959 | MetaboLights
ProteomicsAntagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest
The seminal description of cellular restriction factor APOBEC3G and its antagonism by HIV-1 Vif has underpinned two decades of research on the host-virus interaction. As well as APOBEC3G and its homologues, however, we have recently discovered that Vif is also able to degrade the PPP2R5 family of re...
ORGANISM(S): Homo sapiens (Human) 
2020-04-17 | PXD018271 | Pride
Hiv Pp2a Proteomics Vif 
UnknownThe relationship between dopamine receptor D1 and cognitive performance.
Not available
S-EPMC4849437 | biostudies-literature
ProteomicsFunctional proteomic atlas of HIV-infection in primary human CD4+ T cells
Viruses manipulate host cells to enhance their replication, and the identification of host factors targeted by viruses has led to key insights in both viral pathogenesis and cellular physiology. We previously described global changes in cellular protein levels during human immunodeficiency virus (HI...
ORGANISM(S): Homo sapiens (Human) 
2019-03-08 | PXD012263 | Pride
Proteomics Hiv Primary t-cells 
UnknownEthno-demographic disparities in humoral responses to the COVID-19 vaccine among healthcare workers.
Not available
S-EPMC10536788 | biostudies-literature
UnknownDynamic macromolecular material design: the versatility of cucurbituril over cyclodextrin in host-guest chemistry.
Not available
S-EPMC11334980 | biostudies-literature
UnknownA Novel N-Tetrasaccharide in Patients with Congenital Disorders of Glycosylation, Including Asparagine-Linked Glycosylation Protein 1, Phosphomannomutase 2, and Mannose Phosphate Isomerase Deficiencies.
Not available
S-EPMC4819965 | biostudies-literature
UnknownSite-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking.
Not available
S-EPMC6124414 | biostudies-literature
UnknownAnticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia.
Not available
S-EPMC8440496 | biostudies-literature
ProteomicsQuantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-Cov-2 innate immune evasion
We used two model systems to characterise the changes caused by SARS-CoV-2 using quantitative proteomics. We used primary human epithelial cells differentiated at the air-liquid interface, first describing the relative abundance of proteins found in each major cell type of the epithelium, and then c...
ORGANISM(S): Homo sapiens (Human) 
2022-05-26 | PXD034135 | Pride
Sars-cov-2 Hbec 
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