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ProteomicsThe interacted proteins of ALKBH5 and FTO identified by IP-mass
Since m6A demethylases (FTO and ALKBH5) have been reported to be involved in pre-mRNA splicing regulation, we hypothesized that dynamic m6A distribution during mRNA maturation might involve removal of m6A in internal exons by FTO or ALKBH5 accompanied by splicing factors. To explore this we performe...
ORGANISM(S): Homo sapiens (Human) 
2022-12-09 | PXD038705 | Pride
Alkbh5 Binding proteins Fto 
UnknownA Survey of Spontaneous Antibiotic-Resistant Mutants of the Halophilic, Thermophilic Bacterium Rhodothermus marinus.
Not available
S-EPMC8614978 | biostudies-literature
UnknownBiochemical and mutational analysis of glutamine synthetase type III from the rumen anaerobe Ruminococcus albus 8.
Not available
S-EPMC1272975 | biostudies-literature
UnknownThe tRNA Editing Complex ADAT2/3 Promotes Cancer Cell Growth and Codon-biased mRNA Translation.
Not available
S-EPMC12788883 | biostudies-literature
UnknownDNA methylation is linked to deacetylation of histone H3, but not H4, on the imprinted genes Snrpn and U2af1-rs1.
Not available
S-EPMC87265 | biostudies-literature
GenomicsChromatin accessibility profiling of developing cerebellar granule neurons identifies novel neuronal enhancers and reveals a role for Zic transcription factors in neuronal maturation
To identify chromatin mechanisms of neuronal differentiation, we characterized the relationship between chromatin accessibility and gene expression in cerebellar granule neurons (CGNs) of the developing mouse. We used DNase-seq to globally map accessibility of cis-regulatory elements and RNA-seq to ...
ORGANISM(S): Mus musculus 
2015-02-27 | E-GEOD-60731 | biostudies-arrayexpress
MetabolomicsA homeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism

Cellular senescence affects many physiological and pathological processes and is characterized by durable cell cycle arrest, an inflammatory secretory phenotype and metabolic reprogramming. Here, by using dynamic transcriptome and metabolome profiling in human fibroblasts with different subtypes ...

2024-01-09 | MTBLS7118 | MetaboLights
GenomicsGemone-wide maps of PRC2 complex components and chromatin states in prostate cancer cell lines
We report the high-throughput profiling of PRC2 core subunits chromatin states and histone modifications in two prostate cancer cell lines, androgen-dependent cells LNCaP and androgen-independent cells LNCaP-abl (abl). By obtaining over 1 billion bases of sequence from chromatin immunoprecipitated D...
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-39459 | biostudies-arrayexpress
GenomicsRole of PRC2 complex components in prostate cancer cell lines
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-39461 | biostudies-arrayexpress
UnknownAccelarated immune ageing is associated with COVID-19 disease severity.
Not available
S-EPMC10782727 | biostudies-literature
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