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TranscriptomicsALKBH5 is a New Mammalian RNA Demethylase
N6-methyladenosine (m6A) is the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Here we report ALKBH5 as a new mammalian demethylase that oxidatively removes the m6A modification in mRNA in vitro and inside cells. This demethylation activity of ALKBH5 significantly...
ORGANISM(S): Mus musculus 
2013-02-15 | E-GEOD-40132 | biostudies-arrayexpress
ProteomicsIdentification of the proteins that are associated with ALKBH5 by an affinity purification and mass spectrometry (MS) analysis in human 293T cells.
Our proteomics analysis is for characterization of ALKBH5 protein interactions in 293T cells. We expressed HA-tagged ALKBH5 in 293T cells, prepared nuclear extracts, and subjected them to affinity purification using an anti-HA antibody, followed by mass spectrometry analysis of the purified protein.
ORGANISM(S): Homo sapiens (Human) 
2023-07-26 | PXD042183 | Pride
Human Ap-ms Alkbh5 
ProteomicsIdentification the interactors of the K235-acetylated ALKBH5
The differntial gel band between wild-type ALKBH5-interacted proteins and K235R mutant ALKBH5-interacted proteins was identifed by mass spectrometry.
ORGANISM(S): Homo Sapiens 
2023-04-13 | PXD020071 |
ProteomicsIdentification of the acetylation sites in ALKBH5
The acetylation modification sites in ALKBH5 was identified by mass spectrometry.
ORGANISM(S): Homo Sapiens 
2023-04-13 | PXD020070 |
ProteomicsThe interacted proteins of ALKBH5 and FTO identified by IP-mass
Since m6A demethylases (FTO and ALKBH5) have been reported to be involved in pre-mRNA splicing regulation, we hypothesized that dynamic m6A distribution during mRNA maturation might involve removal of m6A in internal exons by FTO or ALKBH5 accompanied by splicing factors. To explore this we performe...
ORGANISM(S): Homo sapiens (Human) 
2022-12-09 | PXD038705 | Pride
Alkbh5 Binding proteins Fto 
GenomicsTranscriptome analyses of trophoblast upon ALKBH5 knockdown
Transcriptome analyses of trophoblast upon ALKBH5 knockdown
PRJNA526448 | ENA
GenomicsDecreased ALKBH5 in neutrophil correlates with disease activity in rheumatoid arthritis and ALKBH5 modulates neutrophil autophagy
Decreased ALKBH5 in neutrophil correlates with disease activity in rheumatoid arthritis and ALKBH5 modulates neutrophil autophagy
PRJNA1307416 | ENA
GenomicsALKBH5
ALKBH5
PRJNA932008 | ENA
GenomicsEpigenome analysis of ALKBH5 knocked down HCT116 cell
Epigenome analysis of ALKBH5 knocked down HCT116 cell
PRJNA786900 | ENA
GenomicsALKBH5 K235 acetylation regulates the RNA m6A profiles
ALKBH5 K235 acetylation regulates the RNA m6A profiles
PRJNA596205 | ENA
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