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UnknownActivation of the STAT3 signaling pathway is associated with poor survival in diffuse large B-cell lymphoma treated with R-CHOP.
Not available
S-EPMC3871513 | biostudies-literature
TranscriptomicsEffect of methylphenidate on gene expression profiles of Attention Deficit Hyperactivity Disorder patients and unaffected controls.
Attention deficit hyperactivity disorder (ADHD) is a common psychiatric condition of children with a prevalence of 5-10% worldwide. Up to 30% of adults with a history of childhood ADHD maintain symptoms in later life; these adult ADHD patients are severely impaired in social and professional life d...
ORGANISM(S): Homo sapiens 
2014-09-05 | E-GEOD-52889 | biostudies-arrayexpress
TranscriptomicsTargeted RNA-seq (TempO-Seq) of human induced pluripotent stem cell (hiPSC)-derived hepatocyte like cells (HLCs) treated with Nitrofurantoin against control condition
We wanted to investigate the transcriptional effect of Nitrofurantoin, a known drug induced liver injury (DILI)-compound, on hiPSC-derived HLCs. The goal was to identify which srress response pathways and biological processes are activated or altered in HLCs following Nitrofurantoin exposure. The co...
ORGANISM(S): Homo sapiens 
2025-08-09 | E-MTAB-15398 | biostudies-arrayexpress
TranscriptomicsExpression-analysis of human peripheral blood mononuclear cells (PBMC) cocultivated with RT-4 cells transduced with a trivalent adenoviral vector (Im02) for expression of 4-1BBL, IL-12 and IL-2
The trivalent adenoviral vector Im02 encodes the cDNAs for human 4-1BBL, IL-12 and IL-2. This vector was designed to change the immune tumor microenvironment. At the outset, we investigated the immune stimulating effect of Im02 transduced urothelial cancer cells (RT-4). Human PBMCs of a healthy dono...
ORGANISM(S): Homo sapiens 
2021-01-01 | E-MTAB-7615 | biostudies-arrayexpress
TranscriptomicsTargeted RNA-seq (TempO-Seq) of human hepatocellular carcinoma cell line HepG2, primary human hepatocytes (PHHs) and human induced pluripotent stem cell derived hepatocyte like cells (HLCs) in untreated condition
We aimed to compare the baseline expression of liver function and metabolism-related genes across the three liver models. Liver in vitro models are commonly used to study liver biology, disease mechanisms, and drug metabolism. Understanding their baseline gene expression profiles is crucial for inte...
ORGANISM(S): Homo sapiens 
2025-08-09 | E-MTAB-15401 | biostudies-arrayexpress
TranscriptomicsGene Regulation of Intestinal Porcine Epithelial Cells IPECM-bM-^@M-^QJ2 is Dependent on the Site of Deoxynivalenol Toxicological Action
Here we analysed different mechanisms of apical and basolateral deoxynivalenol (DON) toxicity reflected in the gene expression. We used the jejunum derived, polarized intestinal porcine epithelial cell line IPECM-bM-^@M-^QJ2 as an in vitro cell culture model. Luminal and blood stream DON intoxicatio...
ORGANISM(S): Sus scrofa 
2012-12-31 | E-GEOD-33246 | biostudies-arrayexpress
ProteomicsProteomic Profiling of Potential E6AP Substrates via Ubiquitin-based Photo-Crosslinking Assisted Affinity Enrichment
E6AP/UBE3A, the founding member of HECT-type (Homologous to E6AP C-terminus) E3 ligases, is implicated in human papillomaviruses (HPV)-mediated cervical cancer and neurodevelopmental disorders like Angelman and Dup15q syndromes. To elucidate the function of E3 ligases, knowledge about their substrat...
ORGANISM(S): Homo sapiens (Human) 
2025-01-27 | PXD055649 | Pride
Photoaffinity labelling Proteomics Substrate identification Ubiquitination E6ap/ube3a 
GenomicsDeregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment - ChIPseq
PPARD and RXR genome wide binding in tumor associated macrophages from serous ovarian carcinoma was characterized.
ORGANISM(S): Homo sapiens 
2015-06-01 | E-MTAB-3166 | biostudies-arrayexpress
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