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ProteomicsAKT dependent Notch3 activation drives tumor progression in a model of mesenchymal colorectal cancer subtype
Recently a consensus molecular subtype (CMS) classification of colorectal cancer (CRC) has been established that is based on the transcriptional rather than the genetic profile of an individual tumor and which may ultimately help to individualize CRC therapy. So far, however, the lack of appropriate...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD014778 | Pride
Label-free quantification Colorectal cancer Lc/ms Protein phosphorylation 
ProteomicsInflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer
Standard cancer therapy targets tumor cells without considering the possible collateral damage on the tumor microenvironment that could impair therapy response. Employing patient-derived tumor organoids and primary stroma cells or a novel murine rectal cancer model, we show that interleukin-1a (IL-1...
ORGANISM(S): Homo sapiens (Human) 
2022-02-08 | PXD030422 | Pride
Chemoradiotherapy Ffpe Rectal cancer Super-silac 
ProteomicsInflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer
Standard cancer therapy targets tumor cells without considering the possible collateral damage on the tumor microenvironment that could impair therapy response. Employing patient-derived tumor organoids and primary stroma cells or a novel murine rectal cancer model, we show that interleukin-1 (IL-1 ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-08 | PXD020871 | Pride
Chemoradiotherapy Rectal cancer Matrisome Tmt labeling Extracellular matrix 
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