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TranscriptomicsGRHL1 acts as a tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3
Neuroblastoma is an embryonic solid tumor of neural crest origin and accounts for 11% of all cancer-related deaths in children. Novel therapeutic strategies are therefore urgently required. MYCN oncogene amplification, which occurs in 20% of neuroblastomas, is a hallmark of high risk. Here we aimed ...
ORGANISM(S): Homo sapiens 
2014-05-22 | E-GEOD-47407 | biostudies-arrayexpress
ProteomicsIdentification of human GRHL1 interactors and post-translational modifications by LC-MS/MS
Aim of the project was to identify interactors and post-translational modifications of recombinant 3xFLAG-6xHis-tagged human GRHL1, tandem-affinity purified from isolated HEK293 nuclei treated with DMSO as control or with the phytochemical papaverine.
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD021768 | Pride
Interactors Transcription factor Post-translational modification Grhl1 Lc-ms/ms 
UnknownDiscovery of a non-canonical GRHL1 binding site using deep convolutional and recurrent neural networks.
Not available
S-EPMC10696883 | biostudies-literature
UnknownEGFR-ERK induced activation of GRHL1 promotes cell cycle progression by up-regulating cell cycle related genes in lung cancer.
Not available
S-EPMC8087693 | biostudies-literature
TranscriptomicsGRHL1 acts as a tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3
Neuroblastoma is an embryonic solid tumor of neural crest origin and accounts for 11% of all cancer-related deaths in children. Novel therapeutic strategies are therefore urgently required. MYCN oncogene amplification, which occurs in 20% of neuroblastomas, is a hallmark of high risk. Here we aimed ...
ORGANISM(S): Homo sapiens 
2014-05-22 | GSE47407 | GEO
GenomicsMus musculus
Expression data from kidney of Grhl1wt and Grhl1 ko mice.
PRJNA263586 | ENA
GenomicsHomo sapiens
GRHL1 acts as a tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3
PRJNA205520 | ENA
UnknownGrainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan.
Not available
S-EPMC8748497 | biostudies-literature
UnknownPerturbed desmosomal cadherin expression in grainy head-like 1-null mice.
Not available
S-EPMC2274933 | biostudies-literature
UnknownTranscription factors Kruppel-like factor 4 and paired box 5 regulate the expression of the Grainyhead-like genes.
Not available
S-EPMC8476022 | biostudies-literature
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