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TranscriptomicsDual Roles of the Transcription Factor Grainyhead-like 2 (GRHL2) in Breast Cancer
Using a retrovirus-mediated cDNA expression cloning approach we identified the grainyhead-like 2 (GRHL2) transcription factor as novel protooncogene. Overexpression of GRHL2 in NIH3T3 cells induced striking morphological changes, an increase in cell proliferation, anchorage-independent growth, and t...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-43610 | biostudies-arrayexpress
TranscriptomicsGrainyhead-like 2 (GRHL2) maintains the epithelial status of ovarian cancer through miR-200-ZEB1 regulatory networks (expression)
Epithelial ovarian cancer (EOC) is clinically heterogeneous, comprising different histological and biological subtypes. Multiple studies have implicated epithelial-mesenchymal transition (EMT), a biological process by which polarized epithelial cells convert into a mesenchymal phenotype, to contribu...
ORGANISM(S): Homo sapiens 
2016-02-25 | E-GEOD-71017 | biostudies-arrayexpress
TranscriptomicsGrhl2 regulated genes in the mouse lung epithelial MLE15 cell line
The Grainyhead family of transcription factors controls morphogenesis and differentiation of epithelial cell layers in multicellular organisms by regulating cell junction- and proliferation-related genes. Grainyhead-like 2 (Grhl2) is expressed in developing mouse lung epithelium and is required for ...
ORGANISM(S): Mus musculus 
2012-09-10 | E-GEOD-40729 | biostudies-arrayexpress
GenomicsMultiple roles for Grainyhead-like transcription factors in the establishment and maintenance of human mucociliary airway epithelium (ChIP-Seq)
The airways of the human lung are lined by an epithelium made up of ciliated and secretory luminal cells and undifferentiated p63+ Krt5+ basal cells. The integrity of this epithelium and its ability to act as a selective barrier are critical for normal lung function. In other epithelia there is evid...
ORGANISM(S): Homo sapiens 
2013-05-07 | E-GEOD-46194 | biostudies-arrayexpress
GenomicsA Grhl2-dependent gene network controls trophoblast branching morphogenesis [ChIP-seq]
Healthy placental development is essential for reproductive success; failure of the feto-maternal interface results in preeclampsia and intrauterine growth retardation. We found that grainyhead-like 2 (GRHL2), a CP2-type transcription factor, is highly expressed in chorionic trophoblast cells, inclu...
ORGANISM(S): Mus musculus 
2015-03-10 | E-GEOD-65962 | biostudies-arrayexpress
TranscriptomicsGene expression data from primary human bronchial epithelial cells expressing EGFP or DN-GRHL2
The airways of the human lung are lined by an epithelium made up of ciliated and secretory luminal cells and undifferentiated p63+ Krt5+ progenitors. The integrity of this epithelium and its ability to act as a selective barrier are critical for normal lung function. In other epithelia there is evid...
ORGANISM(S): Homo sapiens 
2013-05-08 | E-GEOD-44807 | biostudies-arrayexpress
TranscriptomicsGene expression data from primary human bronchial epithelial cells expressing EGFP or DN-GRHL2 for 48h
The airways of the human lung are lined by an epithelium made up of ciliated and secretory luminal cells and undifferentiated p63+ Krt5+ basal cells. The integrity of this epithelium and its ability to act as a selective barrier are critical for normal lung function. In other epithelia there is evid...
ORGANISM(S): Homo sapiens 
2013-05-08 | E-GEOD-44808 | biostudies-arrayexpress
TranscriptomicsMultiple roles for Grainyheadlike transcription factors in the establishment and maintenance of human mucociliary airway epithelium
The airways of the human lung are lined by an epithelium made up of ciliated and secretory luminal cells and undifferentiated p63+ Krt5+ basal cells. The integrity of this epithelium and its ability to act as a selective barrier are critical for normal lung function. In other epithelia there is evid...
ORGANISM(S): Homo sapiens 
2013-05-07 | E-GEOD-44718 | biostudies-arrayexpress
GenomicsGRHL2 derepression triggers pathophysiological hepatocyte to cholangiocyte transdifferentiation
GRHL2 derepression triggers pathophysiological hepatocyte to cholangiocyte transdifferentiation
PRJNA1183757 | ENA
GenomicsTranscriptomic analysis of GRHL2 regulated genes in BMEL cells
Transcriptomic analysis of GRHL2 regulated genes in BMEL cells
PRJNA1185267 | ENA
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