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TranscriptomicsHey3Met2 human ovarian cancer cells overexpressing wild type or catalytically-dead mutant RNASET2
Hey3Met2 cells were stably transfected with plasmids encoding either wild-type RNASET2 or a catalytically dead form (whose cDNA has been previously mutagenized in the two CAS catalytic sites) or with the empty vector as a control. The control of ovarian tumorigenesis by RNASET2 occurs through modifi...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-28478 | biostudies-arrayexpress
TranscriptomicsRNASET2-silenced and control OVCAR3 cell clones injected into nude mice.
To investigate the molecular pathways underlying RNASET2-mediated tumor suppression in vivo, we investigated the gene expression profile of tumor samples obtained from control and RNASET2-silenced OVCAR3 xenografts, respectively. In order to evaluate the contribution of human cancer cells and the...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-43029 | biostudies-arrayexpress
TranscriptomicsSILENCING OF PNPLA6, THE NEUROPATHY TARGET ESTERASE (NTE) CODIFYING GENE, ALTERS HUMAN NEURODIFFERENTIATION IN VITRO
Neuropathy Target Esterase (NTE) is a protein involved in the development of a polyneuropathy caused by exposure to certain organophosphorus compounds. In vivo and in vitro studies have also associated NTE with embryonic development since NTE null mice embryos are non-viable, and silencing the NTE-c...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-55761 | biostudies-arrayexpress
TranscriptomicsUnderstanding toxicity pathways of gold nanoparticles: RNA expression study on Caco-2 human colon carcinoma cells
A safer design and higher eficacy of nano-gold therapeutic formulations requires examination of cellular responses to gold nanoparticles (AuNPs). In this work we compared cellular uptake, cytotoxicity and RNA expression patterns induced in Caco-2 cells of citrate-stabilized Au NP of two different si...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-55349 | biostudies-arrayexpress
TranscriptomicsWhole genome analysis regulation in HepG2 cells exposed to cadmium
Cadmium (Cd) is a metal present in working and living environments known to be toxic and carcinogenic, but its mechanism of action remains still unclear. We investigated the gene expression modulation in human hepatoma cell line HepG2 after exposure to 2 M-BM-5m and 10 M-BM-5m cadmium using Agilent...
ORGANISM(S): Homo sapiens 
2012-04-30 | E-GEOD-31286 | biostudies-arrayexpress
TranscriptomicsGenomic and phenotypic alterations of the neuronal-like cells derived from the human embryonal carcinoma stem cells (NT2) caused by exposure to the organophosphorus compounds paraoxon and mipafox
hNT2 under neurodifferentiation were exposed during 4 days to 1 µM of the non-neuropathic organophosphorus compound paraoxon and 5 µM of the neuropathic organophosphorus compound and afterwards transcriptomics were analysed and compared regarding control non-exposed cells Exposure to paraoxon caus...
ORGANISM(S): Homo sapiens 
2012-10-18 | E-GEOD-38050 | biostudies-arrayexpress
TranscriptomicsInterlaboratory study to determine the reproducibility of toxicogenomics datasets
The application of toxicogenomics as a predictive tool for chemical risk assessment has been under evaluation by the toxicology community for more than a decade. However, toxicogenomics predominately remains a tool for investigative research rather than for regulatory risk assessment. In this study,...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-25936 | biostudies-arrayexpress
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