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GenomicsGenome-wide binding sites of Progesterone receptor (PGR) isoforms PGR-A and PGR-B during differentiation of human endometrial stromal cells
We report the genome-wide binding sites of PGR-A and PGR-B at 2h of in vitro differentiation of human endometrial stromal cells that express either PGR-A or PGR-B. Progesterone, acting through the progesterone receptors (PGRs), is one of the most critical regulators of endometrial differentiation, k...
ORGANISM(S): Homo sapiens 
2015-04-27 | E-GEOD-62475 | biostudies-arrayexpress
Genomicshuman SU-DHL-5 and TMD-8 B-lymphome cell line subclones
Genetic heterogeneity though common in tumors has been rarely documented in cell lines. To examine how often B-lymphoma cell lines are comprised of subclones, we performed immunoglobulin (Ig) heavy chain hypermutation analysis. Revealing that subclones are not rare in B-cell lymphoma cell lines, 6/4...
ORGANISM(S): Homo sapiens 
2016-09-30 | E-MTAB-4956 | biostudies-arrayexpress
GenomicsThe B Cell Subtypes and VDJ Repertoire of Young Adult Rhesus Macaques
The B Cell Subtypes and VDJ Repertoire of Young Adult Rhesus Macaques
PRJNA1289132 | ENA
UnknownGRIFFIN: a system for predicting GPCR-G-protein coupling selectivity using a support vector machine and a hidden Markov model.
Not available
S-EPMC1160255 | biostudies-literature
GenomicsCharacterizing the profiles of Ebf1 in mouse fat cells (ChIP-seq)
ChIP-seq data from mouse adipocyte. Mature 3T3-L1 adipocytes were cross-linked with 1% formaldehyde 10 days after induction with MDI. Frozen cell pellets were submitted to the Broad Institute for subsequent analysis of Ebf1-bound regions using anti-Ebf1 antibody (Abnova H00001879-M01).
ORGANISM(S): Mus musculus 
2014-06-10 | E-GEOD-58330 | biostudies-arrayexpress
GenomicsB Cell Methylome
Mouse B cells were isolated from the spleen and activated ex vivo. DNA was obtained from activated and control B cells with the Qiagen AllPrep kit. 1ug of DNA was sonicated with the Covaris Sonicator (300bp) and the Illumina library was prepared following a standard Illumina protocol with the NEB Ne...
ORGANISM(S): Mus musculus 
2013-03-25 | E-ERAD-90 | biostudies-arrayexpress
TranscriptomicsCombined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B-cell progenitors
In order to investigate how transcription factor dose impacts B-lymphocyte development, we generated mice carrying transheterozygous mutations in the Pax5 and Ebf1 genes. While combined reduction of Pax5 and Ebf1 dose had minimal impact on the development of the earliest CD19+ progenitors, these cel...
ORGANISM(S): Mus musculus 
2015-05-27 | E-GEOD-69227 | biostudies-arrayexpress
GenomicsPTIP promotes chromatin changes critical for immunoglobulin class switch recombination
Programmed genetic rearrangements in lymphocytes require transcription at antigen receptor genes to promote accessibility for initiating double-strand break (DSB) formation critical for DNA recombination and repair. Here we show that activated B cells deficient in the PTIP component of the MLL3 (mix...
ORGANISM(S): Mus musculus 
2010-08-25 | E-GEOD-20852 | biostudies-arrayexpress
MetabolomicsMicrobial liberation of N-methylserotonin from orange fiber in gnotobiotic mice and humans
Plant fibers in byproduct streams produced by non-harsh food processing methods represent biorepositories of diverse, naturally occurring, and physiologically active biomolecules. To demonstrate one approach for their characterization, mass spectrometry of intestinal contents from gnotobiotic mice, ...
2022-07-28 | MTBLS2331 | MetaboLights
TranscriptomicsRNA-seq of murine spleen B-cells after pentanoate treatment compared to untreated control
We tested the influence of pentanoate on B cells by treatment of CpG-stimulated B cells in vitro. We isolated naive B cells from FIR/TIGER mice (IL-10 (GFP) - Foxp3 (RFP) - Reporter mice) from spleen. Cells were cultured in presence of 5 µg/ml CpG 2395. 24h after CpG-stimulation, B cells were treate...
ORGANISM(S): Mus musculus 
2019-01-15 | E-MTAB-6115 | biostudies-arrayexpress
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