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TranscriptomicsAGO4 Regulates Entry into Meiosis and Influences Silencing of Sex Chromosomes in the Male Mouse Germline
The four mammalian Argonaute family members are thought to share redundant functions in the microRNA pathway, yet only AGO2 possesses the catalytic "slicer" function required for RNA interference. Whether AGO1, AGO3, or AGO4 possess specialized functions remains unclear. Here, we Series_su...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-39652 | biostudies-arrayexpress
TranscriptomicsRapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life
Neonates often generate incomplete immunity against intracellular pathogens, although the mechanism of this defect is poorly understood. An important question is whether the impaired development of memory CD8+ T cells in neonates is due to an immature priming environment or lymphocyte-intrinsic def...
ORGANISM(S): Mus musculus 
2014-05-13 | E-GEOD-56575 | biostudies-arrayexpress
TranscriptomicsRNAseq and Lariat sequencing of different S. pombe growth conditions
We performed lariat sequencing to profile the diversity of spliced RNA lariats in S. pombe identify annotated and alternate introns. Three different growth conditions were used to grow S. pombe wt and S. pombe Δdbr1. Lariat sequencing of the Δdbr1 strains and RNAseq of the wt and Δdbr1 strains were ...
ORGANISM(S): Schizosaccharomyces pombe 
2015-09-03 | E-GEOD-68345 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of hnRNP A2/B1 and A1 depleted cells
We used NEBNext Ultra Directional RNA Library Prep Kits to prepare RNA-seq libraries of total RNA from hnRNP A2/B1 and A1 depleted A549 cells. Pro-seq libraries were prepared from A549 cells using Illumina adapters hnRNP A2/B1 and A1 depleted A549 cells were generated by lentiviral infections of s...
ORGANISM(S): Homo sapiens 
2016-05-17 | E-GEOD-76151 | biostudies-arrayexpress
GenomicsGenome-wide measurement of LPS-induced Poly(A) tail length changes in macrophage cells
Genome-wide measurement of LPS-induced Poly(A) tail length changes in macrophage cells
PRJNA675839 | ENA
TranscriptomicsThe Early Origins and Evolution of microRNAs and piRNAs in Animals
We explored the potential for small RNA biology in organisms that diverged basal to Bilateria, identifying both miRNAs and piRNAs in Nematsotella and Amphimedon Employ HTS of endogenous small RNAs
ORGANISM(S): Nematostella vectensis 
2008-09-30 | E-GEOD-12578 | biostudies-arrayexpress
TranscriptomicsNeonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-09-24 | E-GEOD-65923 | biostudies-arrayexpress
ProteomicsComparative mass spectrometry of extracellular vesicles
Comparison of proteomes for extracellular vesicles in human and mouse breast cancer, and human cell line samples by nano LC-MS/MS after IP pulldown.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-10-14 | PXD025616 | Pride
Breast cancer Extracellular vesicles Human Mouse Mb231 cells 
TranscriptomicsNeonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation [small-RNA seq]
Neonates are intrinsically defective at creating memory CD8+ T cells in response to infection with intracellular pathogens. Here we investigated differential of small RNAs, transcription factors, and chemokine receptors regulation in neonates as compared to adults before and during infection. We fou...
ORGANISM(S): Mus musculus 
2015-09-24 | E-GEOD-65920 | biostudies-arrayexpress
TranscriptomicsNeonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation [3'UTR-seq]
Neonates are intrinsically defective at creating memory CD8+ T cells in response to infection with intracellular pathogens. Here we investigated differential of small RNAs, transcription factors, and chemokine receptors regulation in neonates as compared to adults before and during infection. We fou...
ORGANISM(S): Mus musculus 
2015-09-24 | E-GEOD-65921 | biostudies-arrayexpress
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