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ProteomicsDesign and synthesis of tailored human caseinolytic protease P inhibitors
Human caseinolytic protease P (hClpP) is important for degradation of misfolded proteins in the mitochondrial unfolded protein response. We here introduce tailored hClpP inhibitors that utilize a steric discrimination in their core naphthofuran scaffold to selectively address the human enzyme. This ...
ORGANISM(S): Homo sapiens (Human) 
2019-03-05 | PXD010277 | Pride
Mitochondria Jurkat Clpp Huh7 Phenyl esters 
ProteomicsSubstrate profiling of mitochondrial caseinolytic protease P via a site-specific photocrosslinking approach
The function of proteases is mainly determined by the substrates they are processing. However, substrate identification remains a challenging task. Here, we used genetic code expansion to incorporate a diazirine-lysine amino acid (DiazK) at selected positions of mitochondrial caseinolytic protease P...
ORGANISM(S): Homo sapiens (Human) 
2023-08-22 | PXD027954 | Pride
Mtupr Mitochondria Photoaffinity crosslinking Clpxp Orbitrap fusion 
ProteomicsMulti-center longitudinal quality assessment of MS-based proteomics in plasma and serum
Advancing MS-based proteomics towards clinical applications evolves around developing standardized start-to-finish and fit-for-purpose workflows for clinical specimens. Steps along the method design involve the determination and optimization of several bioanalytical parameters such as selectivity, s...
ORGANISM(S): Homo sapiens (Human) 
2025-02-14 | PXD054073 | Pride
Plasma Serum Round robin study R package mpwr Lc-ms/ms 
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