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TranscriptomicsEffect of insulin infusion on human skeletal muscle
To identify insulin responsive genes in humans, in the first protocol, skeletal muscle biopsies from six non-diabetic subjects were obtained before and after a two-hour of hyperinsulinaemic (infusion rate 40 mU/m2/min) euglycemic clamp. A variable infusion of glucose (180 g/l) enriched with tritiate...
ORGANISM(S): Homo sapiens 
2007-03-01 | E-GEOD-7146 | biostudies-arrayexpress
UnknownMapping the Cord Blood Transcriptome of Pregnancies Affected by Early Maternal Anemia to Identify Signatures of Fetal Programming.
Not available
S-EPMC9016468 | biostudies-literature
TranscriptomicsGlobal transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism [expression array]
Here we harnessed the potential of expression arrays in 89 human pancreatic islet donors (different levels of blood glucose (HbA1c)) to identify genes regulated in this relevant tissue for type 2 diabetes (T2D). Islets from cadaver donors were provided by the Nordic Islet Transplantation Programme (...
ORGANISM(S): Homo sapiens 
2014-07-17 | E-GEOD-50397 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-07-17 | E-GEOD-50398 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism [RNA-seq]
Here we harnessed the potential of RNA sequencing in 89 human pancreatic islet donors to identify genes and exons regulated in this relevant tissue for T2D. mRNA profiles of 89 human pancreatic islet donors having different levels of blood glucose (HbA1c) with and without T2D. The data was generated...
ORGANISM(S): Homo sapiens 
2014-07-17 | E-GEOD-50244 | biostudies-arrayexpress
TranscriptomicsExpression microarray analysis of human pancreatic islets reveals CD59 function
Pancreatic islets are central in type 2-diabetes development, which coincides with increased activity of innate immunity. Intriguingly, human pancreatic islets express many complement genes. The most highly expressed gene was the complement inhibitor CD59 that is GPI anchored to the cell membrane, w...
ORGANISM(S): Homo sapiens 
2014-03-02 | E-GEOD-54279 | biostudies-arrayexpress
TranscriptomicsExpression data from human pancreatic islets
A gene co-expression network analysis has been conducted to identify T2D-associated gene modules. Donors 1-48 were used for the initial analysis and donors 49-80 for the replication and were normalized separately in this study Islets from cadaver donors (57 non-diabetic and 20 diabetic) were provide...
ORGANISM(S): Homo sapiens 
2012-10-23 | E-GEOD-41762 | biostudies-arrayexpress
TranscriptomicsExpression/Transcription profiling by high throughput sequencing of TCF7L2 KD and control in INS1 832/13 cells
Genetic variants in TCF7L2 are the most highly associated variants with type 2 diabetes.We performed RNA_seq experiments on Control and Knockdown samples for 4 passages each. Library preparation was performed according to mRNA Sequening Sample Preparation Guide (illumina). Reagents were taken from t...
ORGANISM(S): Rattus norvegicus 
2013-12-15 | E-MTAB-2034 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance
Background. Differential gene expression in adipose tissue during diet-induced weight loss followed by a weight stability period is not well characterized. Markers of these processes may provide a deeper understanding of the underlying mechanisms. Objective. To identify differentially expressed gen...
ORGANISM(S): Homo sapiens 
2012-01-31 | E-GEOD-35411 | biostudies-arrayexpress
GenomicsImperial College London - Beta Cell Genome Regulation Lab
Data Access Committee EGAC00001000853
EGAC00001000853 | EGA
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