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ProteomicsCombined proteomics/genomics approach reveals proteomic changes of mature virions as a novel poxvirus adaption mechanism
DNA viruses, like poxviruses, possess a highly stable genome, suggesting adaption of virus particles to specific cell types is not restricted to genomic changes. Cowpox viruses (CPXV) are zoonotic poxviruses with an extraordinary broad host range, demonstrating their adaptive potential in vivo. To e...
ORGANISM(S): Cowpox virus (CPV) 
2017-11-14 | PXD007567 | Pride
Poxvirus Adaption Cowpox virus Lc-ms/ms 
ProteomicsCowpox virus proteomics reveals massive ubiquitination and proteasomal degradation of viral proteins but stable virus cores
The ubiquitin-proteasome system (UPS) is essential for replication of Orthopoxviruses (OPV) like vaccinia and cowpox virus (CPXV). Although several proteome studies identified ubiquitin as part of OPV particles, distinct modification sites are largely unknown. Moreover, the UPS plays a key role in p...
ORGANISM(S): Cowpox virus Cowpox virus (CPV) 
2018-02-07 | PXD006426 | Pride
Ubiquitination Viral proteomics Orthopoxvirus 
ProteomicsDeep time-course proteomics of SARS-CoV and SARS-CoV-2 infected human lung epithelial cells (Calu-3) reveals strong induction of interferon-stimulated gene (ISG) expression by SARS-CoV-2 in contrast to SARS-CoV
In the present study, we used data-independent acquisition mass spectrometry (DIA-MS) to analyse the protein expression in Calu-3 cells infected with SARS-CoV and SARS-CoV-2 over the time-course of 24 hours. About 8400 proteins were identified, from which about 90% could be quantified across the exp...
ORGANISM(S): Homo sapiens (Human) Severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome-related coronavirus 
2022-01-20 | PXD024883 | Pride
Sars-cov-2 Sars-cov Calu-3 Human lung cells 
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