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ProteomicsThe endothelial inflammatory repertoire: a multi-omic delineation of cytokine induced endothelial inflammatory states
Vascular endothelial cells (ECs) form a dynamic interface between blood and tissue and play a crucial role in the progression of vascular inflammation. Here, we explored the underlying molecular mechanisms of endothelial-cytokine responses which govern inflammation. Applying an unbiased cytokine lib...
ORGANISM(S): Homo sapiens (Human) 
2023-05-17 | PXD036582 | Pride
Mult-omics Inflammation Endothelial cells 
ProteomicsTargeting synergetic endothelial inflammation by inhibiting NFKB and JAK-STAT pathways
Multiple systemic vascular inflammatory disorders are associated with endothelial dysfunction and elevated levels of TNFα and IFNγ. Combined TNFα and IFNγ stimulation induces synergetic hyperinflammation in endothelial cells (ECs) through activation of the NFKB and JAK/STAT pathways. Here we assess ...
ORGANISM(S): Homo sapiens (Human) 
2025-07-17 | PXD064921 | Pride
Proteomics Inflammation Inhibitors Endothelial cells 
ProteomicsEndothelial inflammation inhibitor screen
[placeholder] Endothelial inflammation is an important factor in endothelial dysfunction. TNFa and IFNg induce unique inflammation state in ECs, which is synergistically amplified when both are combined. Here we propose targeted inhibition of endothelial inflammation employing an unbiased proteomics...
ORGANISM(S): Homo sapiens (Human) 
2025-07-17 | PXD058294 | Pride
Proteomics Inflammation Inhibitors Endothelial cells 
ProteomicsThe Proteomic Landscape of in vitro Cultured Endothelial Cells across Vascular Beds
Blood vessel endothelial cells (EC) display heterogeneity across vascular beds, which is at the bases of organ specificity and anticipated to drive site-specific vascular pathology. It is assessed in vivo using transcriptomics, and in vitro using functional assays, but how proteomes compare across h...
ORGANISM(S): Homo sapiens (Human) 
2024-07-25 | PXD045899 | Pride
In vitro Cardiac Brain Aorta Lung Liver Kidney Boec Huvec Endothelial cells 
ProteomicsRemoving the mutant: Allele-selective knock-out ameliorates VWD type 2 in patient-derived ECFCs
Treatment of von Willebrand disease (VWD) has been topic of discussions and research for several decades. The (genetic) heterogeneity of the inherited bleeding disorder remains one of the biggest obstacles for proper treatment, as well as the high costs of (recombinant) factor concentrates of VWF. I...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD064937 | Pride
Vwd Peptide analysis Endothelial cells Variant detection Allele knockout 
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