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MetabolomicsArginine-induced metabolomic perturbation in Streptococcus mutans

BACKGROUND: Streptococcus mutans is a major pathogen responsible for dental caries. Arginine is a promising potential caries preventive agent which can inhibit the growth of S. mutans. However, the mechanism whereby arginine inhibits S. mutans growth r...

2023-10-20 | MTBLS3020 | MetaboLights
MetabolomicsAirway metabolic profiling during Streptococcus pneumoniae infection identifies branched chain amino acids as signatures of upper airway colonisation

Streptococcus pneumoniae is a leading cause of community-acquired pneumonia and bacteraemia and is capable of remarkable phenotypic plasticity, responding rapidly to environmental change. Pneumococcus is a nasopharyngeal commensal, but is responsible for severe, acute infections followin...

2023-08-08 | MTBLS4591 | MetaboLights
TranscriptomicsAnalysis of the group A Streptococcus CcpA Transcriptome
This study evaluate how catabolite control protein A (CcpA) inactivation affected gene transcript levels in the group A Streptococcus serotype M1 strain MGAS5005 during growth in standard laboratory medium. Keywords: transcriptome analysis 4 replicates of strain MGAS5005 and delta_cppA were grown in...
ORGANISM(S): Streptococcus sp. 'group A' 
2010-05-26 | E-GEOD-10156 | biostudies-arrayexpress
TranscriptomicsA genome-wide analysis of small regulatory RNAs in the human pathogen group A Streptococcus
This SuperSeries is composed of the following subset Series: GSE17767: Transcriptome comparison of Streptococcus pyogenes strain MGAS2221 with that of an isogenic PEL mutant GSE17789: Tiling microarray-based identification of small regulatory RNAs in the group A Streptococcus (GAS) Refer to individu...
ORGANISM(S): Streptococcus pyogenes 
2009-08-25 | E-GEOD-17790 | biostudies-arrayexpress
MetabolomicsBioplatforms Australia: Antibiotic Resistant Sepsis Pathogens Framework Initiative (Streptococcus pyogenes assays)

The Antibiotic Resistant Sepsis Pathogens Framework Initiative aims to develop a framework dataset of 5 sepsis pathogens (5 strains each) using an integrated application of genomic, transcriptomic, metabolomic and proteomic technologies. The pathogens included in this initiative are: Escheric...

2022-08-03 | MTBLS2324 | MetaboLights
TranscriptomicsInsert in CovS Gene Distinguishes a Pharyngeal and a Blood Isolate of Streptococcus pyogenes Found in the Same Individual.
Expression of the extensive arsenal of virulence factors by Streptococcus pyogenes are controlled by many regulators, of which covR/S is one of the best characterized and can influence ~15% of the genome. Animal models have established that mutants of CovR/S arise spontaneously in vivo resulting in ...
ORGANISM(S): Streptococcus pyogenes 
2010-05-01 | E-GEOD-21316 | biostudies-arrayexpress
TranscriptomicsDetermination of transcriptome of SptR in group A Streptococcus during growth in human saliva
The molecular genetic mechanisms used by bacteria to persist in humans are poorly understood. Group A Streptococcus (GAS) causes the majority of bacterial pharyngitis cases in humans and is prone to persistently inhabit the upper respiratory tract. To gain information about how GAS survives in and i...
ORGANISM(S): Streptococcus sp. 'group A' 
2010-05-19 | E-GEOD-16124 | biostudies-arrayexpress
ProteomicsSpxA1 and SpxA2 Function as a Stoichiometry-Dependent Regulatory Rheostat Governing Virulence Gene Expression in Group A Streptococcus — DIA Proteomics
Group A Streptococcus (GAS) encodes two paralogs of the Spx transcriptional regulator, SpxA1 and SpxA2, which interact with RNA polymerase to modulate virulence gene expression. SpxA2 is directly regulated by the LiaFSR three-component system in response to antimicrobial peptide stress. To define ho...
ORGANISM(S): Streptococcus pyogenes MGAS315 
2026-07-13 | PXD079489 | Pride
Spx Group a streptococcus Covr 
TranscriptomicsTranscriptome analysis of wt and PerR mutant Group A streptococcus (GAS), strain 003Sm in THB medium, with and without hydrogen peroxide
Transcriptome analysis of of wt and PerR mutant Group A streptococcus strain 003Sm grown in the presence or absence of hydrogen peroxide, at early and late log
ORGANISM(S): Streptococcus pyogenes 
2011-11-18 | E-MTAB-646 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of wt and PerR mutant Group A streptococcus (GAS), strain 003Sm in THB medium, with and without hydrogen peroxide
Transcriptome analysis of of wt and PerR mutant Group A streptococcus strain 003Sm grown in the presence or absence of hydrogen peroxide, at early and late log
ORGANISM(S): Group A streptococcus 
2011-12-31 | E-MTAB-628 | biostudies-arrayexpress
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