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TranscriptomicsSubcellular expression profiling of the growth cones of retinal ganglion cells (RGC)
Cue-directed axon guidance depends partly on local translation in growth cones. Many mRNA transcripts are known to reside in developing axons yet little is known about their subcellular distribution or, specifically, which transcripts are in growth cones. Laser capture microdissection (LCM) was used...
ORGANISM(S): Xenopus laevis 
2010-11-23 | E-GEOD-25166 | biostudies-arrayexpress
ProteomicsProteomic analysis of growth cones from WT and HD mice
Although Huntington’s disease (HD) is a late onset neurological condition, studies suggest a developmental contribution to its adult manifestations. Imaging studies in presymptomatic HD gene carriers revealed early alterations in white matter tract with a marked defect in the corpus callosum. This t...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-08 | PXD023885 | Pride
Growth cone Huntington’s disease Lc-ms/ms 
ProteomicsProteomic profile of hippocampal growth cones through early postnatal development
During early postnatal development, hippocampal circuits are assembled through the coordinated navigation of axonal growth cones toward their synaptic targets. While growth cones are known to rely on local proteomic changes to interpret guidance cues, the developmental dynamics of their proteomic co...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-11 | PXD076616 | Pride
Local translation Proteomics Hippocampus Early postnatal development Brain tissue Growth cones Transgenic mouse line Lc-ms/ms 
TranscriptomicsmiR-124 acts through coREST to control the onset of Sema3A sensitivity in navigating retinal growth cones
During axon pathfinding, growth cones commonly exhibit changes in sensitivity to guidance cues that follow a strict timetable, even in the absence of pathway feedback, implicating cell-intrinsic regulation. Cellular timer mechanisms, however, are poorly understood. Here we have investigated microRNA...
ORGANISM(S): Xenopus laevis 
2011-12-12 | E-GEOD-33444 | biostudies-arrayexpress
GenomicsSubcellular expression profiling of the growth cones of retinal ganglion cells (RGC)
Subcellular expression profiling of the growth cones of retinal ganglion cells (RGC)
PRJNA134423 | ENA
TranscriptomicsExpression data of wild type and C-DGCR8 KO cones at different timepoints [RNA-seq]
We have analyzed gene expression in cone photoreceptors isolated from wild type and C-DGCR8 (DiGeorge Syndrome Critical Region Gene 8) KO mice at five different time points to get a mechanistic inside into the altered molecular pathways after microRNAs depletion. Cones were isolated by FACS from wil...
ORGANISM(S): Mus musculus 
2014-06-20 | E-GEOD-58498 | biostudies-arrayexpress
TranscriptomicsExpression data of wild type and C-DGCR8 KO cones at different timepoints [array]
We have analyzed gene expression in cone photoreceptors isolated from wild type and C-DGCR8 (DiGeorge Syndrome Critical Region Gene 8) KO mice at five different time points to get a mechanistic inside into the altered molecular pathways after microRNAs depletion. Cones were isolated by FACS from wil...
ORGANISM(S): Mus musculus 
2014-06-20 | E-GEOD-58493 | biostudies-arrayexpress
TranscriptomicsSubcellular expression profiling of the growth cones of retinal ganglion cells (RGC)
Cue-directed axon guidance depends partly on local translation in growth cones. Many mRNA transcripts are known to reside in developing axons yet little is known about their subcellular distribution or, specifically, which transcripts are in growth cones. Laser capture microdissection (LCM) was used...
ORGANISM(S): Xenopus laevis Mus musculus 
2010-11-23 | GSE25166 | GEO
TranscriptomicsTranscriptomes From the Deep Cones During FIbroproliferative Cutaneous Healing in the Duroc/Yorkshire Porcine Model
The goal was to obtain the differential transcriptome in the deep cones between shallow and deep wounds and between the Yorkshire and Duroc breeds over time. We made shallow and deep wounds on the backs of 3 Yorkshire and 3 Duroc pigs, biopsied the wounds at 1 2 3 12 and 20 weeks, extracted and ampl...
ORGANISM(S): Sus scrofa 
2011-12-31 | E-GEOD-26095 | biostudies-arrayexpress
UnknownSynCAM 1 participates in axo-dendritic contact assembly and shapes neuronal growth cones.
Not available
S-EPMC2867738 | biostudies-literature
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