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TranscriptomicsHuman cortical organoids. Chronic treatment with GSK3 inhibitor CHIR99021. Bulk RNAseq.
Here we used human cortical brain organoids to probe the longitudinal impact of GSK3 inhibition through multiple developmental stages. Chronic GSK3 inhibition increased the proliferation of neural progenitors and caused massive derangement of cortical tissue architecture. Cortical organoids were dif...
ORGANISM(S): Homo sapiens 
2020-06-04 | E-MTAB-8325 | biostudies-arrayexpress
ProteomicsPolyubiquitination analysis upon GSK3 inhibition in HeLa cell extracts
HeLa cell extracts with or without GSK3 enzyme inhibition were assayed using protein microarrays in order to detect GSK3-dependent changes in protein polyubiquitination. HeLa lysates in triplicates were supplemented with ubiquitin and incubated on protein microarrays (ProtoArray 5.0; Invitrogen) in ...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-50629 | biostudies-arrayexpress
GenomicsEffect of GSK3 inhibition on the transcriptional signature of human monocytes
Effect of GSK3 inhibition on the transcriptional signature of human monocytes
PRJNA1080033 | ENA
GenomicsEffect of GSK3 inhibition on the transcriptional signature of human alveolar macrophages
Effect of GSK3 inhibition on the transcriptional signature of human alveolar macrophages
PRJNA1091920 | ENA
GenomicsChIP-seq of Klf2 in mouse embryonic stem cells (Serum/LIF and 2i)
The self-renewing pluripotent state was first captured in mouse embryonic stem cells (mESCs) over two decades ago. The standard condition requires the presence of serum and LIF, which provide growth promoting signals for cell expansion. However, there are pro-differentiation signals which destabiliz...
ORGANISM(S): Mus musculus 
2014-06-04 | E-MTAB-2365 | biostudies-arrayexpress
GenomicsRNA-Seq for transcriptome analysis of germinal center B cells upon GSK3 inhibition
RNA-Seq for transcriptome analysis of germinal center B cells upon GSK3 inhibition
PRJNA603488 | ENA
TranscriptomicsSingle cell RNAseq of human cortical organoids investigating the effect of chronic treatment with GSK3 inhibitor CHIR99021
Here we used human cortical brain organoids to probe the longitudinal impact of GSK3 inhibition through multiple developmental stages. Chronic GSK3 inhibition increased the proliferation of neural progenitors and caused massive derangement of cortical tissue architecture. Cortical organoids were dif...
ORGANISM(S): Homo sapiens 
2020-06-09 | E-MTAB-8337 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array of Klf2 wild-type and Klf2-Null mESCs cultured under 2i
The self-renewing pluripotent state was first captured in mouse embryonic stem cells (mESCs) over two decades ago. The standard condition requires the presence of serum and LIF, which provide growth promoting signals for cell expansion. However, there are pro-differentiation signals which destabiliz...
ORGANISM(S): Mus musculus 
2014-06-04 | E-MTAB-2366 | biostudies-arrayexpress
TranscriptomicsGene expression in astrocytes upon sustained GSK-3 inhibition by small molecule
In order to identify molecular targets that mediates the stimulation of astrocyte's migration upon sustained specific inhibition of GSK-3, we have employed whole genome microarray expression profiling. Murine cortical-striatal astrocytes grown in primary culture were treated in vitro for 48 h with e...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-25770 | biostudies-arrayexpress
ProteomicsPolyubiquitination analysis upon GSK3 inhibition in HeLa cell extracts
HeLa cell extracts with or without GSK3 enzyme inhibition were assayed using protein microarrays in order to detect GSK3-dependent changes in protein polyubiquitination.
ORGANISM(S): Homo sapiens 
2014-05-15 | GSE50629 | GEO
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