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GenomicsGSK3a/b restrains IFNg-inducible costimulatory molecule expression in alveolar macrophages, limiting CD4+ T cell activation
GSK3a/b restrains IFNg-inducible costimulatory molecule expression in alveolar macrophages, limiting CD4+ T cell activation
PRJNA998748 | ENA
TranscriptomicsGSK3a/b restrains IFNg-inducible costimulatory molecule expression in alveolar macrophages, limiting CD4+ T cell activation
Macrophages play a crucial role in eliminating respiratory pathogens. Both pulmonary resident alveolar macrophages (AMs) and recruited macrophages contribute to detecting, responding to, and resolving infections in the lungs. Despite their distinct functions, it remains unclear how these macrophage ...
ORGANISM(S): Mus musculus 
2023-08-16 | GSE239280 | GEO
TranscriptomicsEffect of siRNA-mediated GSK3 knock-down on the transcriptional signature of human GM-CSF-dependent monocyte-derived macrophages
The functional versatility of macrophages is intrincately tied to factors such as their ontogeny and the specific tissue and extracellular environment. Monocyte-derived macrophages are oppositely instructed by M-CSF or GM-CSF. GM-CSF drives monocyte-derived macrophages towards heightened pro-inflamm...
ORGANISM(S): Homo sapiens 
2025-04-16 | GSE266236 | GEO
UnknownGSK3A promotes human adenovirus replication and phosphorylates viral L4-22K protein.
Not available
S-EPMC12179656 | biostudies-literature
UnknownGSK-3 modulates SHH-driven proliferation in postnatal cerebellar neurogenesis and medulloblastoma.
Not available
S-EPMC6826032 | biostudies-literature
TranscriptomicsRNA-Seq of human pancreas organoids in expansion conditions in the presence of DMSO, CHIR99021 or CHIR99021 in the absence of FGF2
To investigate signaling pathways regulating human pancreas differentiation and morphogenesis, we developed a high-content image-based screen and quantitative multivariate analysis pipelines robust to heterogeneity to extract single-cell and organoid features using pancreatic progenitor organoids. A...
ORGANISM(S): Homo sapiens 
2026-01-21 | E-MTAB-16105 | biostudies-arrayexpress
UnknownNon-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection.
Not available
S-EPMC8188550 | biostudies-literature
TranscriptomicsDifferential gene expression and splicing in apc mutant zebrafish
APC is a classical tumor suppressor in humans, and truncating mutations are early somatic events in most cases of sporadic colon cancer. APC directly enhances the activity of glycogen synthase kinase 3 (GSK-3) and therefore loss of full length APC reduces GSK-3 activity, leading to stabilization of ...
ORGANISM(S): Danio rerio 
2023-06-19 | GSE234986 | GEO
GenomicsEffect of siRNA-mediated GSK3 knock-down on the transcriptional signature of human GM-CSF-dependent monocyte-derived macrophages
Effect of siRNA-mediated GSK3 knock-down on the transcriptional signature of human GM-CSF-dependent monocyte-derived macrophages
PRJNA1106426 | ENA
GenomicsGlycogen synthase kinase-3 is essential for Treg development and homeostasis
Glycogen synthase kinase-3 is essential for Treg development and homeostasis
PRJNA1162894 | ENA
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