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MetabolomicsIntegrating two chromatographies in a co-fractionation mass spectrometry approach improved protein-metabolite interactions (PMIs) mapping capabilities and revealed novel protein-ligand pairings in Escherichia coli.
The protein-metabolite interactome remains understudied. We previously developed a co-fractionation mass-spectrometry-based approach called PROMIS to address this gap. PROMIS relies on size separation chromatography of protein-metabolite complexes from lysates, followed by proteomics and metabolomic...
2025-04-25 | MTBLS9098 | MetaboLights
GenomicsG3BP2-KIT drives leukemia amenable to kinase inhibition in Ph-like ALL
We describe a patient with Ph-like ALL, in which leukemic cells harbored an in-frame fusion between the GTPase-activating protein (SH3 domain)-binding protein 2 (G3BP2) and the KIT proto-oncogene.
EGAS00001005181 | EGA
ProteomicsTMEM55B mediates lysosomal positioning via TBC1D9B, a GTPase-activating protein (GAP) for Arl8gb.
TMEM55B mediates lysosomal positioning via TBC1D9B, a GTPase-activating protein (GAP) for Arl8gb.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-23 | MSV000095685 | MassIVE
GenomicsDysregulation of GTPase-activating protein-binding protein1 in the pathogenesis of metabolic dysfunction-associated steatotic liver disease
Dysregulation of GTPase-activating protein-binding protein1 in the pathogenesis of metabolic dysfunction-associated steatotic liver disease
PRJNA1301331 | ENA
UnknownThe Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton.
Not available
S-EPMC18133 | biostudies-literature
TranscriptomicsHuman-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion
The evolutionary expansion of the human neocortex reflects increased amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Here, we analyze the transcriptomes of distinct progenitor subpopulations isolated by a novel approach from developi...
ORGANISM(S): Homo sapiens 
2015-03-02 | E-GEOD-65000 | biostudies-arrayexpress
UnknownSolution structure and dynamics of the mitochondrial-targeted GTPase-activating protein (GAP) VopE by an integrated NMR/SAXS approach.
Not available
S-EPMC9047041 | biostudies-literature
UnknownSite-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.
Not available
S-EPMC3537887 | biostudies-literature
UnknownCrystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases.
Not available
S-EPMC5368074 | biostudies-literature
UnknownBiological characterization of Drosophila Rapgap1, a GTPase activating protein for Rap1.
Not available
S-EPMC25011 | biostudies-literature
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