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MetabolomicsATG9A-PLA2G6 axis reprograms phospholipid metabolism to drive metabolic liver disease and hepatocellular carcinoma

The liver orchestrates systemic metabolism, and its dysfunction drives diseases including metabolic dysfunction-associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC). ATG9A, an autophagy-related transmembrane protein and lipid scramblase, regulates lipid dynamics, yet its ...

2025-10-24 | MTBLS12451 | MetaboLights
ProteomicsConstitutive Protein Kinase G Activation Exacerbates Stress-induced Cardiomyopathy
: Heart failure is associated with high morbidity and mortality, and new therapeutic targets are needed. Preclinical data suggest that pharmacological activation of protein kinase G (PKG) can reduce maladaptive ventricular remodeling and cardiac dysfunction in the stressed heart. However, clinical...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD022600 | Pride
Lc-msms Protein kinase g 
UnknownInvestigation of possible G-quadruplex formation by GU- and GA-rich repeats and their role in translation.
Not available
S-EPMC12710887 | biostudies-literature
GenomicsG-Quadruplex structural motifs modulate protein-RNA interactions within the transcriptome
G-Quadruplex structural motifs modulate protein-RNA interactions within the transcriptome
PRJNA1198313 | ENA
TranscriptomicsG-Quadruplex structural motifs modulate protein-RNA interactions within the transcriptome
RNA secondary structures, including G-quadruplexes (G4s), have emerged as vital players in protein–RNA interactions. The RNA-binding protein Fused in Sarcoma (FUS), which is strongly implicated in both neurodegenerative disease and cancer, is known to interact with RNA molecules through a variety of...
ORGANISM(S): Homo sapiens 
2025-09-06 | GSE284272 | GEO
UnknownA novel algorithm- specific loci screening accelerates the establishment of molecular quantification of Glycyrrhiza glabra, G. uralensis, and G. inflata.
Not available
S-EPMC12642167 | biostudies-literature
UnknownPlant-Expressed Receptor Binding Domain of the SARS-CoV-2 Spike Protein Elicits Humoral Immunity in Mice.
Not available
S-EPMC8472882 | biostudies-literature
UnknownAnionic G•U pairs in bacterial ribosomal rRNAs.
Not available
S-EPMC10275268 | biostudies-literature
UnknownNoncanonical G(syn)-G(anti) base pairs stabilized by sulphate anions in two X-ray structures of the (GUGGUCUGAUGAGGCC) RNA duplex.
Not available
S-EPMC2525959 | biostudies-literature
ProteomicsSelenite metabolism and reduction in Ganoderma lucidum
G. lucidum could reduce selenite to element Se and further aggregated into selenium nanoparticles (SeNPs), simultaneously accompanying by the production of pungent odorous volatile selenium metabolites. iTRAQ-based quantitative proteomic analysis revealed the abundance of proteins involved in sele...
ORGANISM(S): Ganoderma Lucidum G.260125-1 
2022-08-03 | PXD035786 |
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