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TranscriptomicspiRNAs initiate an epigenetic memory of non-self RNA in the C. elegans germline.
Organisms exhibit a fascinating array of gene-silencing pathways, which have evolved in part, to confront invasive nucleic acids such as transposons and viruses. A key question raised by the existence of these pathways is how do they distinguish M-bM-^@M-^\selfM-bM-^@M-^] from M-bM-^@M-^\non-selfM-b...
ORGANISM(S): Caenorhabditis elegans 
2012-07-17 | E-GEOD-38724 | biostudies-arrayexpress
ProteomicsCharacterization of m-lipin using HDX-MS
This project consists of two experiments. The first is mapping the binding interface between the isolated m-lip domain of mouse lipin and liposomes. The second experiments is mapping the binding interface between full length mouse lipin and liposomes. Looking at the isolated m-lip domain, we found t...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-29 | PXD022172 | Pride
M-lip domain Mass spectrometry M-lipin Hdx-ms 
UnknownU1A inhibits cleavage at the immunoglobulin M heavy-chain secretory poly(A) site by binding between the two downstream GU-rich regions.
Not available
S-EPMC434241 | biostudies-literature
MetabolomicsBased on the Metabolomic Approach the Energy Metabolism Responses of Oriental River Prawn Macrobrachium nipponense Hepatopancreas to Acute Hypoxia and Reoxygenation
Hypoxia represents a major physiological challenge for prawns and is a problem in aquaculture. Therefore, an understanding of the metabolic response mechanism of economically important prawn species to hypoxia and re-oxygenation is essential. However, little is known about the intrinsic mechanisms b...
2021-05-17 | MTBLS584 | MetaboLights
TranscriptomicsExpression of ZAP-70 in CLL activates NF-M-NM-:B signaling
Chronic lymphocytic leukemia (CLL) is a disease with a highly variable prognosis. The clinical course can however be predicted thanks to prognostic markers. Poor prognosis is associated with expression of a B cell receptor (BCR) from unmutated immunoglobulin variable heavy-chain genes (IgVH) and exp...
ORGANISM(S): Homo sapiens 
2013-10-22 | E-GEOD-51286 | biostudies-arrayexpress
TranscriptomicsTranscriptome of Mycoplasma genitalium under osmotic stress
Mycoplasma genitalium is the causative agent of non-gonococcal, chlamydia-negative urethritis in men and has been linked to reproductive tract disease syndromes in women. As with other mycoplasmas, M. genitalium lacks many regulatory genes because of its streamlined genome and total dependence on a ...
ORGANISM(S): Mycoplasma genitalium 
2010-11-15 | E-GEOD-22661 | biostudies-arrayexpress
TranscriptomicsC. elegans piRNAs are processed from capped-small RNAs transcribed at promoters throughout the genome
Piwi-interacting (pi) RNAs are a class of germline-expressed small RNAs that have been linked to epigenetic programming in metazoa. C. elegans piRNAs known as 21U-RNAs are defined by more than 15,000 genome-encoded species. To explore the origin of 21U-RNAs we employed methods to enrich the 5' ends ...
ORGANISM(S): Mus musculus 
2012-12-22 | E-GEOD-40053 | biostudies-arrayexpress
GenomicsAn improved SELEX-Seq strategy for characterizing DNA-binding specificity of transcription factor: NF-M-NM-:B as an example
We provided an improved SELEX-Seq strategy for characterizing DNA-binding specificity of transcription factor. We valided the strategy by characterzing the DNA-binding specificty of NF-M-NM-:B p50 dimer. Proteins of the Nf-kappab family were bound to DNA oligonucleotides containing a degenerate regi...
ORGANISM(S): Homo sapiens 
2014-05-05 | E-GEOD-48660 | biostudies-arrayexpress
UnknownIRAK-M Deficiency Exacerbates Ischemic Neurovascular Injuries in Experimental Stroke Mice.
Not available
S-EPMC6308305 | biostudies-literature
UnknownAnalysis of Dispersion of Carbon Nanotubes in m-Cresol.
Not available
S-EPMC9181108 | biostudies-literature
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