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TranscriptomicsThe transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection
Inflammasomes are critical for mounting host defense against pathogens. The molecular mechanisms that control activation of the AIM2 inflammasome in response to different cytosolic pathogens remain unclear. Here we found that the transcription factor IRF1 was required for the activation of the AIM2 ...
ORGANISM(S): Mus musculus 
2015-03-04 | E-GEOD-66461 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human colorectal carcinoma patients expressing either high or low levels of human guanylate binding protein-1 (GBP-1) to identify coregulated genes
The gene expression profile of 24 human colorectal carcinoma patients either expressing high (n=12) or low (n=12) levels of human guanylate binding protein-1 (GBP-1) were compared in order to identify coregulated genes.
ORGANISM(S): Homo sapiens 
2008-07-31 | E-MEXP-833 | biostudies-arrayexpress
UnknownHuman guanylate binding proteins potentiate the anti-chlamydia effects of interferon-gamma.
Not available
S-EPMC2714978 | biostudies-literature
TranscriptomicsTranscription profiling of human soluble guanylate cyclase-deficient U937 cells exposed to the nitric oxide (NO) donor S-nitrosoglutathione to provide insight into the cGMP-independent effects of NO
NO effects on gene expression, independent of cGMP, were examined globally. Differentiated human U937 cells that lack soluble guanylate cyclase were exposed to Snitrosoglutathione, a NO donor, or glutathione without or with dibutyryl-cAMP (Bt2cAMP). NO regulated 110 transcripts that annotated dispro...
ORGANISM(S): Homo sapiens 
2007-09-11 | E-GEOD-2649 | biostudies-arrayexpress
UnknownA Rapidly Evolving Polybasic Motif Modulates Bacterial Detection by Guanylate Binding Proteins.
Not available
S-EPMC7240152 | biostudies-literature
UnknownThe Nucleoporin CPR5 Modulates Plant Immunity via Guanylate-Binding Proteins.
Not available
S-EPMC12034427 | biostudies-literature
UnknownInterferon-induced guanylate-binding proteins in inflammasome activation and host defense.
Not available
S-EPMC4961213 | biostudies-literature
UnknownHuman guanylate binding proteins: nanomachines orchestrating host defense.
Not available
S-EPMC8196077 | biostudies-literature
UnknownGuanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules.
Not available
S-EPMC3243629 | biostudies-literature
UnknownFunctional cross-species conservation of guanylate-binding proteins in innate immunity.
Not available
S-EPMC9005921 | biostudies-literature
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