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We used ChIP-seq to characterize the genome-wide binding sites of NF90/ILF3 in K562 erythroleukemia cells.
ORGANISM(S): Homo sapiens 
GATA1-binding sites constituted essential functional elements within the HS2 enhancer, enabling transcription factor recruitment, enhancer activation, and long-range chromatin interactions at the β-globin locus. In K562 cells, a human erythroleukemia line that expresses fetal and embryonic globin ge...
ORGANISM(S): Homo sapiens 
Aberrant TGFbeta signalling is a hallmark of epithelial derived tumours. Signalling patterns can depend on the membrane trafficking and internalization of the TGFbeta receptors. Protein kinase C (PKC), particularly the atypical PKC isoforms, alter the trafficking of TGFbeta receptors and can alter T...
ORGANISM(S): Homo sapiens 
Transcriptional profiling of Drosophila embryos comparing lola mutant 10-12 hour after egg lay (AEL) embryos to age-matched control embryos. Mutants are homozygous isoform K nulls (allele lola_ORC4). Two-condition experiment: lola mutant embryos vs. age-matched control embryos. 7 biological replicat...
ORGANISM(S): Drosophila melanogaster 
GATA factors interact with simple DNA motifs (WGATAR) to regulate critical processes, including hematopoiesis, but very few WGATAR motifs are occupied in genomes. Given the rudimentary knowledge of mechanisms underlying this restriction, and how GATA factors establish genetic networks, we used ChIP-...
ORGANISM(S): Homo sapiens 
Overexpression of antiapoptotic BCL2 family proteins occurs in various hematologic malignanices and contributes to leukemogenesis by inhibiting the apoptotic machinery of the cells. BH3 mimetics provide an option for medication, with venetoclax as the first drug applied for chronic lymphocytic leuke...
ORGANISM(S): Homo sapiens 
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