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Sequencing of sorted alveolar macrophages (AMs) from WT mice, or from SPAM deleter (SPecific AM deleter; Siglecf-fl-DTR-fl x Epx-Cre) mice with adoptively transferred donor AMs, treated with PBS or 3 x interleukin-33 (IL33). Experiment 1 compares AMs from PBS treated and IL-33 treated WT mice and AM...
ORGANISM(S): Mus musculus 
Alpha1-antitrypsin (AAT) mutations cause retention of the otherwise secreted protein and lead to the proteotoxic AAT deficiency (AATD)-related liver disease (AATD-LD). As mechanistic target of rapamycin (mTOR) is a key coordinator of proteostasis, we studied its role in AATD-LD. PiZ mice overexpress...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-14 | PXD061881 | Pride
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