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ProteomicsTMT-based phosphoproteomic analysis of ALK-positive patient-derived lung cancer cell lines with GUK1 phospho-null mutation and ALK TKI treatment
The metabolic adaptations observed in cancer are widely recognized, yet the precise mechanisms of how these metabolic adjustments support tumor growth remain unclear. This study explores the impact of guanine nucleotide metabolism on cancer progression in ALK-driven lung cancer. We showed that GUK1 ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-03 | PXD049284 | Pride
Alk Guk1 Phosphoproteomics Non small cell lung cancer 
ProteomicsGUK1 activation is a metabolic liability in oncogene-driven lung cancer
Little is known about metabolic vulnerabilities in oncogene-driven lung cancer. Here, we performed a phosphoproteomic screen in anaplastic lymphoma kinase (ALK)-rearranged (“ALK+”) patient-derived cell lines and identified guanylate kinase 1 (GUK1), a GDP-synthesizing enzyme, as a novel target of AL...
ORGANISM(S): Homo sapiens (Human) 
2025-01-29 | PXD053405 | Pride
Purine nucleotides Guanylate kinase 1 (guk1) Metabolic dependency Tyrosine kinase inhibitor (tki) Lung cancer Non-small cell lung cancer (nsclc) Guanosine diphosphate (gdp) Tumor metabolism Ras Signaling Anaplastic lymphoma kinase (alk) 
UnknownGUK1 activation is a metabolic liability in lung cancer.
Not available
S-EPMC12148050 | biostudies-literature
UnknownGuanylate Kinase 1 Deficiency: A Novel and Potentially Treatable Mitochondrial DNA Depletion/Deletions Disease.
Not available
S-EPMC11563867 | biostudies-literature
UnknownPrefoldin Promotes Proteasomal Degradation of Cytosolic Proteins with Missense Mutations by Maintaining Substrate Solubility.
Not available
S-EPMC4957761 | biostudies-literature
UnknownThe Atypical Guanylate Kinase MoGuk2 Plays Important Roles in Asexual/Sexual Development, Conidial Septation, and Pathogenicity in the Rice Blast Fungus.
Not available
S-EPMC5732230 | biostudies-literature
UnknownGene expression signatures of coronary heart disease.
Not available
S-EPMC3684247 | biostudies-literature
UnknownCharacterization of the impact of GMP/GDP synthesis inhibition on replicative lifespan extension in yeast.
Not available
S-EPMC7367712 | biostudies-literature
UnknownPervasive Divergence in Protein Thermostability is Mediated by Both Structural Changes and Cellular Environments.
Not available
S-EPMC12227239 | biostudies-literature
UnknownDysregulation of purine nucleotide biosynthesis pathways modulates cisplatin cytotoxicity in Saccharomyces cerevisiae.
Not available
S-EPMC2574737 | biostudies-literature
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