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MetabolomicsNPM-ALK metabolic regulation
Not available
ORGANISM(S): Homo sapiens 
ST000016 | MetabolomicsWorkbench
TranscriptomicsExpression of SUDHL-1 cell line treated by ALK inhibitors
In this study we compared the effects of ALK inhibitor on the gene expression, activation of cell signaling pathways, and functional properties of cells derived from a patient with Anaplastic Large Cell Lymphoma. we used microarrays to map the genome-wide gene expression patterns in ALK+TCL cells in...
ORGANISM(S): Homo sapiens 
2013-10-31 | E-GEOD-50803 | biostudies-arrayexpress
TranscriptomicsRegulation of gene expression in ALK inhibitor CH5424802-treated NCI-H2228 xenograft tumors
To clarify the downstream signal pathway of EML4-ALK in NSCLC, we performed Affymetrix GeneChip analysis using ALK inhibitor CH5424802-treated NCI-H2228 xenograft tumors, and comprehensively characterized the gene expression regulated by inhibition of activated ALK. Mice bearing NCI-H2228 cells were...
ORGANISM(S): Mus musculus 
2011-06-03 | E-GEOD-25118 | biostudies-arrayexpress
ProteomicsThe EML4-ALK Interactome in Lung Cancer
We experimentally generated an ALK interactome combining quantitative tyrosine phosphoproteomics and protein complex annotation using affinity purification coupled with mass spectrometry and further investigated downstream ALK signaling using quantitative tyrosine phosphoproteomics.
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD004935 | Pride
Human Eml4-alk Interactome Lung cancer 
ProteomicsSpatial evaluation of transcriptomic and proteomic data in ALK rearranged lung cancer - a pilot study
Spatial evaluation of transcriptomic and proteomic data in ALK rearranged lung cancer - a pilot study
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-04-20 | MSV000089286 | MassIVE
ProteomicsALK fusion NSCLC oncogenes promote survival and inhibit NK cell responses via SERPINB4 expression
Anaplastic lymphoma kinase (ALK) fusion variants in non-small-cell-lung cancer (NSCLC) consist of numerous dimerising fusion partners, with the most common being EML4. Clinical data suggests that the degree of treatment benefit in response to ALK tyrosine kinase inhibitors (TKIs) differs among the v...
ORGANISM(S): Homo sapiens (Human) 
2023-02-16 | PXD035100 | Pride
Human Nsclcl Orbitrap fusion lumos 
ProteomicsProteomics analysis of ALK signaling in neuroblastoma cells
We used mass spectrometry-based proteomics to unravel anaplastic lymphoma kinase (ALK) signaling in the ALK and MYCN amplified neuroblastoma cell line, NB1. We specifically measured the ALK interactome, phosphoproteome, phosphotyrosine interactome and proteome as outlined below. ALK Interactome and ...
ORGANISM(S): Homo sapiens (Human) 
2018-11-21 | PXD006404 | Pride
Lc-msms Neuroblastoma Alk signaling Human 
ProteomicsDisruption of the ALK tumor cell proteome by concurrent inhibition of ALK and SRC kinases.
Precision oncology has revolutionized the treatment of ALK-positive lung cancer with targeted therapies. However, refractory tumors with compound mutations or diverse resistance mechanisms remain an unmet clinical need. In this study, we established mouse tumor-derived cell models representing the m...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-11 | PXD043012 | Pride
Eml4-alk Precision oncology Non-small cell lung cancer (nsclc) Tyrosine kinase inhibitors (tkis) (phospho)proteomic 
TranscriptomicsTranscription profiling of human anaplastic large cell lymphoma cell lines - kinase signature
Anaplastic Large Cell Lymphomas (ALCL) represent a subset of lymphomas in which the Anaplastic Lymphoma Kinase (ALK) gene is frequently fused to the NPM gene. We previously demonstrated that the constitutive phosphorylation of ALK chimeric proteins is sufficient to induce cellular transformation in ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6184 | biostudies-arrayexpress
TranscriptomicsGeneration of NPM1-ALK translocation in human T lymphocytes faithfully recapitulates the diversity of ALK+ ALCL tumor phenotype
To recapitulate the t(2;5)(p23;q35) chromosomal translocation, activated T lymphocytes from healthy donors PBMC were transfected with the RNP complex composed of the protein Cas9 with gRNA NPM1 (targeting NPM1 gene) and gRNA ALK (targeting ALK gene). Control cells were wild-type CD4+ activated lymp...
ORGANISM(S): Homo sapiens 
2022-02-09 | E-MTAB-10924 | biostudies-arrayexpress
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